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Table II Independent Variables Values Used in Plackett-Burman Design

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Independent variables Low level (−) High level (+)
Amount of punches (pcs) 2 6
Table speed (rpm) 16 25
Feeder speed (rpm) 10 15
Pre-compression force (kN) 0.5 1.0
Main compression force (kN) 2.0 8.0
Carrier type Granfiller-DTM 215 GalenIQTM 721
Melatonin type Micronized Non-micronized