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Table X The Independent Variables and Responses Summary Obtained from Fractional Factorial Design

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Trial number Independent variable Dependent variables
Main compression force (kN) Table speed (rpm) Amount of punches (pcs) Resistance to crushing (N) Resistance to crushing SD1 Disintegration time (s) Friability (%) Weight SD Resistance to crushing TXT (N)
1 6 13 2 4.00 1.02 5.00 0.44 0.16 7.52
2 6 18 10 4.10 1.01 4.00 0.44 0.22 6.27
3 6 23 6 4.20 1.24 2.33 0.43 0.19 6.70
4 10 18 6 4.30 0.83 3.67 0.33 0.09 10.29
5 10 18 10 5.20 1.15 4.00 0.37 0.28 11.04
6 10 23 2 4.70 0.94 3.67 0.43 0.14 7.17
7 14 13 6 7.60 1.28 5.00 0.36 0.43 12.72
8 14 18 2 5.40 0.77 2.00 0.42 0.18 11.81
9 14 23 10 5.50 1.55 3.67 0.41 0.32 11.69
10C2 10 18 6 4.70 0.87 4.33 0.33 0.09 11.10
11C2 10 18 6 4.40 1.43 5.33 0.33 0.11 11.63
12C2 10 18 6 6.30 1.34 4.33 0.45 0.36 11.49
  1. 1SD, standard deviation; 2C, center point