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Table I Composition of the Minitablets According to Plackett-Burman, Fractional Factorial, and Full Factorial Design

From: Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

Ingredient name Ingredient amount in the minitablet (mg)
Design type
Plackett-Burman1 Plackett-Burman2 Fractional factorial/fullfactorial
Melatonin 0.501 0.501 0.501
GalenIQTM 721 5.109 - -
Granfiller-DTM 215 - 5.289 5.347
Crospovidone 0.180 - -
Flavor 0.030 0.030 0.008
Aspartame - - 0.024
Magnesium stearate 0.180 0.180 0.120
  1. 1Run No.: 2–3; 6–7; 10–11; 14–15
  2. 2Run No.: 1–4; 5–8; 9–12; 13–16
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