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Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma

  • Review Article
  • Theme: Advances in Topical Delivery of Drugs
  • Published:
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Abstract

Melanoma is regarded as the fifth and sixth most common cancer in men and women, respectively, and it is estimated that one person dies from melanoma every hour in the USA. Unfortunately, the treatment of melanoma is difficult because of its aggressive metastasis and resistance to treatment. The treatment of melanoma continues to be a challenging issue due to the limitations of available treatments such as a low response rate, severe adverse reactions, and significant toxicity. Natural polyphenols have attracted considerable attention from the scientific community due to their chemopreventive and chemotherapeutic efficacy. It has been suggested that poorly soluble polyphenols such as curcumin, resveratrol, quercetin, coumarin, and epigallocatechin-3-gallate may have significant benefits in the treatment of melanoma due to their antioxidant, anti-inflammatory, antiproliferative, and chemoprotective efficacies. The major obstacles for the use of polyphenolic compounds are low stability and poor bioavailability. Numerous nanoformulations, including solid lipid nanoparticles, polymeric nanoparticles, micelles, and liposomes, have been formulated to enhance the bioavailability and stability, as well as the therapeutic efficacy of polyphenols. This review will provide an overview of poorly soluble polyphenols that have been reported to have antimetastatic efficacy in melanomas.

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Authors and Affiliations

  1. School of Pharmacy and Health Professionals, Creighton University, Omaha, Nebraska, 68178, USA

    Gayathri Heenatigala Palliyage, Somnath Singh & Harsh Chauhan

  2. Department of Pharmaceutical Sciences, College of Pharmacy, St. John’s University, New York City, New York, USA

    Charles R. Ashby Jr

  3. Department of Pharmacology & Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, Frederic and Mary Wolfe Center, 3000 Arlington Ave., MS 1015, Toledo, Ohio, 43614, USA

    Amit K. Tiwari

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Heenatigala Palliyage, G., Singh, S., Ashby, C.R. et al. Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma. AAPS PharmSciTech 20, 250 (2019). https://doi.org/10.1208/s12249-019-1457-1

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