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In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review

  • Review Article
  • Theme: Advancements in Dissolution Testing of Oral and Non-Oral Formulations
  • Published:
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Abstract

This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration–time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction.

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Malaysia

    Ravi Sheshala, Nor Khaizan Anuar & Nor Hayati Abu Samah

  2. Non-Destructive Biomedical and Pharmaceutical Research Centre, iPROMISE, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Bandar Puncak Alam, Malaysia

    Nor Khaizan Anuar & Tin Wui Wong

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  1. Ravi Sheshala
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  2. Nor Khaizan Anuar
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  3. Nor Hayati Abu Samah
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Correspondence to Tin Wui Wong.

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Sheshala, R., Anuar, N.K., Abu Samah, N.H. et al. In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review. AAPS PharmSciTech 20, 164 (2019). https://doi.org/10.1208/s12249-019-1362-7

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