Delivery Systems as Vital Tools in Drug Repurposing
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The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs.
KEY WORDSnanocarriers drug delivery systems nanoparticles drug development combination drugs
The authors are grateful to Thomases Family Endowment and Dr. Colene Young Memorial Fund. Dharani Manickavasagam helped with literature compilation.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
- 2.Hahn K. Old drugs are new again, vol. 566. Plainsboro, NJ: Intellisphere, LLC; 2011.Google Scholar
- 9.Sciences NCfAT. Early-Stage Repurposing [Webpage]. 6701 Democracy Boulevard, Bethesda MD 20892–4874: US Department of Health and Human Services; 2018 [updated 8–20-18. Available from: https://ncats.nih.gov/preclinical/repurpose/early. Accessed 22 June 2018.
- 14.Tranfaglia MR, Thibodeaux C, Mason DJ, Brown D, Roberts I, Smith R, et al. Repurposing available drugs for neurodevelopmental disorders: the fragile X experience. Neuropharmacology. 2018. https://doi.org/10.1016/j.neuropharm.2018.05.004.
- 23.Deguchi S, Otake H, Nakazawa Y, Hiramatsu N, Yamamoto N, Nagai N. Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats injected with streptozotocin. Int J Mol Sci. 2017;18(12):2720.Google Scholar
- 29.Marcus S. Beyond repurposing: the case for creating new chemical entities by modifying existing molecules: Genetic Engineering and Biotechnology News August 28, 2017 [Available from: https://www.genengnews.com/gen-exclusives/beyond-repurposing-the-case-for-creating-new-chemical-entities-by-modifying-existing-molecules/77900970. Accessed 22 June 2018.
- 32.Bonelli P, Tuccillo FM, Federico A, Napolitano M, Borrelli A, Melisi D, et al. Ibuprofen delivered by poly(lactic-co-glycolic acid) (PLGA) nanoparticles to human gastric cancer cells exerts antiproliferative activity at very low concentrations. Int J Nanomedicine. 2012;7:5683–91.CrossRefGoogle Scholar
- 38.Eskinazi-Budge A, Manickavasagam D, Czech T, Novak K, Kunzler J, Oyewumi MO. Preparation of emulsifying wax/GMO nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration. Drug Dev Ind Pharm. 2018;44(10)1583–90.Google Scholar
- 43.Xiao Y, Wang S, Zong Q, Yin Z. Co-delivery of metformin and paclitaxel via folate-modified pH-sensitive micelles for enhanced anti-tumor efficacy. AAPS PharmSciTech. 2018;19(5)2395–406.Google Scholar