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Assessing Aerosol Performance of a Dry Powder Carrier Formulation with Increasing Doses Using a Novel Inhaler

  • Research Article
  • Theme: Paul Myrdal Memorial Issue - Pharmaceutical Formulation and Aerosol Sciences
  • Published:
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Abstract

This study aims to investigate the implications of loaded formulation mass on aerosol performance using a reservoir novel dry powder inhaler containing a custom dosing cup to deliver carrier-based formulation to the lungs. A 3D printed dosing cup with volume size of 133.04 mm3 was manufactured to allow for the progressive loading of different carrier formulation masses of 1% beclomethasone dipropionate BDP (w/w) formulation (10 to 60 mg, with increments of 10 mg), in a novel customizable DPI device. Scanning electron micrographs were used to investigate BDP detachment from carrier particles post-aerosolisation and particle deposition on the USP induction port. The subsequent aerosol performance analysis was performed using the next generation impactor (NGI). Incrementally increasing the loading mass to 60 mg led to decreases in BDP detachment from carrier particles, resulting in significant decreases in aerosol performance. Increases in loading dose mass led to progressively decreased detachment of BDP from the carrier and the overall aerosol performance in comparison to the initial mass of 10 mg. These results are likely to be due to a decrease in void volume within the dosing cup with increased loading mass leading to altered airflow, decreased impaction forces and the possibility of a significant quantity of large carrier particles introducing a ‘sweeping’ effect on the inhaler inner surface. This study has shown that despite the decreased BDP detachment from the carrier and decreased aerosol performance, the dose delivered to the lung still increased due to the higher loaded dose.

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Acknowledgements

Australian Research Council ARC LP120200744.

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Authors and Affiliations

  1. Respiratory Technology, the Woolcock Institute for Medical Research and Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia

    Stewart Yeung, Daniela Traini & Paul M. Young

  2. Chiesi Limited, Chippenham, Wiltshire, UK

    Alan Tweedie, David Lewis & Tanya Church

  3. 431 Glebe Point Road, Glebe, NSW, 2037, Australia

    Paul M. Young

Authors
  1. Stewart Yeung
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  2. Daniela Traini
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  3. Alan Tweedie
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  4. David Lewis
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  5. Tanya Church
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  6. Paul M. Young
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Correspondence to Paul M. Young.

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Guest Editors: Philip J. Kuehl and Stephen W. Stein

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Yeung, S., Traini, D., Tweedie, A. et al. Assessing Aerosol Performance of a Dry Powder Carrier Formulation with Increasing Doses Using a Novel Inhaler. AAPS PharmSciTech 20, 94 (2019). https://doi.org/10.1208/s12249-019-1302-6

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  • DOI: https://doi.org/10.1208/s12249-019-1302-6

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