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Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review

  • Review Article
  • Theme: Lipid-Based Drug Delivery Strategies for Oral Drug Delivery
  • Published:
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Abstract

Lipids have been extensively used in formulations to enhance dissolution and bioavailability of poorly water-soluble as well as water-soluble drug molecules. The digestion of lipid-based formulations, in the presence of bile salts, phospholipids, and cholesterol, changes the lipid composition in vivo, resulting in the formation of different colloidal phases in the intestine. Therefore, in vitro characterization and evaluation of such formulations are critical in developing a successful formulation. This review covers comprehensive discussion on in vitro characterization techniques such as solubility, drug entrapment, thermal characterization, dissolution, and digestion of lipid-based formulations.

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Acknowledgments

The author (Nitin Kumar Swarnakar) expresses his sincere gratitude to Western University of Health Sciences, Pomona, California for awarding post-doctoral fellowship to carry out this project.

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  1. Nitin Kumar Swarnakar & Natarajan Venkatesan

    Present address: TesoRx Centre of Excellence at Western University of Health Sciences, 3670 W. Temple Ave, Suite 270, Pomona, California, 91768, USA

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  1. College of Pharmacy, Western University of Health Sciences, Pomona, California, 91766, USA

    Nitin Kumar Swarnakar, Natarajan Venkatesan & Guru Betageri

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  1. Nitin Kumar Swarnakar
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Swarnakar, N.K., Venkatesan, N. & Betageri, G. Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review. AAPS PharmSciTech 20, 16 (2019). https://doi.org/10.1208/s12249-018-1239-1

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