AAPS PharmSciTech

, Volume 19, Issue 7, pp 2921–2928 | Cite as

Research Progress of Raman Spectroscopy in Drug Analysis

  • Wen-ting WangEmail author
  • Hua Zhang
  • Yuan Yuan
  • Ya Guo
  • Shi-xin He
Review Article


Raman spectroscopy is a spectroscopic analysis technique that enables rapid qualitative and quantitative detection based on inelastic collision and Raman scattering intensity. This review detailed the generation principle, instrument composition, influencing factors, and common classifications of Raman spectrum. Furthermore, it summarized and forecast the research progress of Raman spectroscopy in the field of drug analysis simultaneously over the past decade, including the identification of active pharmaceutical ingredients (APIs), qualitative and quantitative studies of pharmaceutical preparations, detection of illicit drugs, the identification of Chinese herbal medicines, and the combination with other technologies. The development of Raman spectroscopy in other fields is additionally summarized.


Raman spectroscopy drug analysis trace detection qualitative and quantitative study 



Wen-ting Wang wants to convey her personal thanks to Yang Yang especially, who is known as an excellent actor. It is his positive energy that she has got through the difficulties.

Funding Information

This review has been supported by drug department of Wanzhou Institute for Food and Drug Control.


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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Wen-ting Wang
    • 1
    Email author
  • Hua Zhang
    • 1
  • Yuan Yuan
    • 2
  • Ya Guo
    • 1
  • Shi-xin He
    • 1
  1. 1.Wanzhou Institute for Food and Drug ControlChongqingChina
  2. 2.Xian Libang Pharmaceutical Co., Ltd.XianChina

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