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Characterization and In Vitro Permeation Study of Cubic Liquid Crystal Containing Sinomenine Hydrochloride

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Abstract

This study developed a new transdermal delivery system for the improved delivery of sinomenine hydrochloride (SH). The delivery system utilized the advantages of lyotropic liquid crystals (LLC) creating an adaptable system that offers a variety of options for the field of transdermal delivery. The formulation was prepared, characterized, and evaluated for its skin penetration in vitro. In the study, the appearance of samples was characterized by visual observation, and these LLC gels were colorless and transparent. Polarizing light microscopy (PLM) and small-angle X-ray diffraction (SAXS) were used to analyze the internal structures of gels, and the gels displayed a cubic double-diamond (Pn3m) internal structure with a dark field of vision. The Franze diffusion cell was used to evaluate its skin penetration. There were several factors which might influence the skin penetration of drugs, such as drug loading, water content, and the layer spacing of the LLC. In our case, drug concentration gradient played a more powerful role. The result of in vitro permeation studies demonstrated that the drug concentration was higher; the cumulative osmotic quantity of SH (Q) was greater. Therefore, the system was a promising formulation for successful percutaneous delivery of SH through the skin.

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Acknowledgements

The content is solely the responsibility of the authors and does not necessarily represent the official views of China Pharmaceutical University.

Funding

The authors are grateful for financial support from the National Natural Science Foundations of China (No. 81274099, No. 81072537), the Anhui Provincial Natural Science Foundation (No. 1408085QH183), Key University natural science research project of Anhui province (KJ2018A0301), and the Exploratory Research Projects of Anhui University of Chinese Medicine (No. 2016ts066).

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Authors and Affiliations

  1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China

    Xiaoqin Chu & Jianqin Jiang

  2. School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, Anhui Province, China

    Xiaoqin Chu, Qian Li, Shuangying Gui, Zhengguang Li & Jiaojiao Cao

  3. Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, Anhui Province, China

    Xiaoqin Chu & Shuangying Gui

  4. Cellular and Molecular Biology Center, China Pharmaceutical University, Nanjing, 211198, Jiangsu Province, China

    Jianqin Jiang

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  1. Xiaoqin Chu
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Chu, X., Li, Q., Gui, S. et al. Characterization and In Vitro Permeation Study of Cubic Liquid Crystal Containing Sinomenine Hydrochloride. AAPS PharmSciTech 19, 2237–2246 (2018). https://doi.org/10.1208/s12249-018-1018-z

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