Encapsulation of Sorbitan Ester-Based Organogels in Alginate Microparticles
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Leaching of the internal apolar phase from the biopolymeric microparticles during storage is a great concern as it undoes the beneficial effects of encapsulation. In this paper, a novel formulation was prepared by encapsulating the sunflower oil-based organogels in alginate microparticles. Salicylic acid and metronidazole were used as the model drugs. The microparticles were prepared by double emulsion methodology. Physico-chemical characterization of the microparticles was done by microscopy, FTIR, XRD, and DSC studies. Oil leaching studies, biocompatibility, mucoadhesivity, in vitro drug release, and the antimicrobial efficiency of the microparticles were also performed. The microparticles were found to be spherical in shape. Gelation of the sunflower oil prevented leaching of the internal phase from the microparticles. Release of drugs from the microparticles followed Fickian kinetics and non-Fickian kinetics in gastric and intestinal environments, respectively. Microparticles showed good antimicrobial activity against both Gram-positive (Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria. The results suggested that the developed formulations hold promise to carry oils without leakage of the internal phase. Encapsulation of organogels within the microparticles has improved the drug entrapment efficiency and improved characteristics for controlled delivery applications.
KEY WORDSalginate drug delivery leaching microparticles organogels
The funds leveraged from the project (SR/FT/LS-171/2009), sanctioned by the Science and Engineering Research Board (SERB), Govt. of India are hereby acknowledged. Authors are thankful to the National Institute of Technology-Rourkela (NIT-R) for providing the instrumental facilities. Sai S. Sagiri is thankful for the scholarship provided by the NIT-R for his doctoral studies. The authors would like to extend their sincere appreciation to the Deanship of Scientific Research (DSR) at the King Saud University for extending the instrumental support for this research through the Research Group Project No. RGP-VPP-345.
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