Comparative Study to Investigate the Effect of Meloxicam or Minocycline HCl In Situ Gel System on Local Treatment of Periodontal Pockets
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In situ gelling formulations allow easy application to the target area. Gelation is induced by physiological stimuli at the site of application where the formula attains semisolid properties and exerts sustained drug release. In situ gelling formulations containing either 3% meloxicam (Mx) or 2% minocycline HCl (MH) were prepared for local application into the periodontal pockets. Gel formulations were based on the thermosensitive Pluronic® (Pl) and the pH-sensitive Carbopol® (C) polymers. C gels were prepared in combination with HPMC (H) to decrease its acidity. The total percent drug released from Pl formulae was 21.72% after 1 week for Mx and 85% after 3 days for MH. Their release kinetics data indicated anomalous non-Fickian behavior that could be controlled by both diffusion and chain relaxation. Addition of MH to C/H gels (1:2.5) resulted in liquefaction, followed by drug precipitation. Regarding C/H gel containing Mx, it showed a prolonged release rate up to 7 days with an initial burst effect; the kinetics data revealed Fickian-diffusion mechanism. The in vitro antibacterial activity studies for MH gel in Pl revealed that the drug released exceeded the minimum inhibitory concentration (MIC) of MH against Staphylococcus aureus ATCC 6538; placebo gel showed no effect on the microorganism. Clinical evaluation of Pl gels containing either Mx or MH showed significant improvement in chronic periodontitis patients, manifested by decrease in pocket depth and gingival index and increase in bone density.
KEY WORDSantiinflammatory antimicrobial Carbopol® clinical evaluation periodontitis pH-sensitive Pluronic® thermosensitive
Special thanks to the staff members of the Department of Periodontology, Oral Medicine, Oral diagnosis and Radiology, Faculty of Dentistry, Alexandria University, Egypt: Prof. Dr. Maha A. Abu-Khedr, Prof. Dr. Sabah A. Mahmoud, Prof. Dr. Shahira A. El-Domiaty and Dentist Nevine A. Abo El Khair, for their valuable effort in the clinical evaluation of the selected formulae in this research.
Conflict of Interest
This manuscript has not been published and is not under consideration for publication elsewhere, and we have no conflict of interest to disclose.
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