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Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine

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Abstract

To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.

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ACKNOWLEDGMENTS

The authors would like to thank University Grants Commission, Government of India, for their financial support.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai, 400019, India

    Meer Tarique Ali, Ritesh Fule, Ajay Sav & Purnima Amin

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  1. Meer Tarique Ali
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  2. Ritesh Fule
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  3. Ajay Sav
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  4. Purnima Amin
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Correspondence to Meer Tarique Ali.

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Ali, M.T., Fule, R., Sav, A. et al. Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine. AAPS PharmSciTech 14, 919–926 (2013). https://doi.org/10.1208/s12249-013-9985-6

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  • DOI: https://doi.org/10.1208/s12249-013-9985-6

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