AAPS PharmSciTech

, Volume 14, Issue 3, pp 919–926 | Cite as

Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine

  • Meer Tarique Ali
  • Ritesh Fule
  • Ajay Sav
  • Purnima Amin
Research Article

Abstract

To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.

KEY WORDS

carbamazepine dissolution solubility enhancement 

Notes

ACKNOWLEDGMENTS

The authors would like to thank University Grants Commission, Government of India, for their financial support.

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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  • Meer Tarique Ali
    • 1
  • Ritesh Fule
    • 1
  • Ajay Sav
    • 1
  • Purnima Amin
    • 1
  1. 1.Department of Pharmaceutical Sciences and TechnologyInstitute of Chemical TechnologyMumbaiIndia

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