AAPS PharmSciTech

, Volume 14, Issue 2, pp 838–846 | Cite as

Development and Characterization of Propranolol Selective Molecular Imprinted Polymer Composite Electrospun Nanofiber Membrane

  • Prasopchai Tonglairoum
  • Wanita Chaijaroenluk
  • Theerasak Rojanarata
  • Tanasait Ngawhirunpat
  • Prasert Akkaramongkolporn
  • Praneet Opanasopit
Research Article


Propranolol (PPL) imprinted microspheres (MIP) were successfully prepared via oil/water polymerization using a methyl methacrylate (MMA) monomer, PLL template, and divinylbenzene (DVB) cross-linker and favorably incorporated in a Eudragit-RS100 nanofiber membrane. A non-PPL imprinted polymer (NIP), without a template, was used as a control. The morphology and particle size of the beads were investigated using scanning electron microscopy. The results revealed that both MIP and NIP had a spherical shape with a micron size of approximately 50–100 μm depending on the amounts of DVB and PPL used. NIP2 (MMA/DVB, 75:2.5) and MIP8 (PPL/MMA/DVB, 0.8:75:2.5) were selected for reloading of PPL, and the result indicated that increasing the ratio of PPL to polymer beads resulted in increase PPL reloading (>80%). A total of 10–50% NIP2 or MIP8 was incorporated into a 40% (w/v) Eudragit-RS100 fiber membrane using an electrospinning technique. PPL could be bound to the 50% MIP8 composite fiber membrane with a higher extent and at a higher rate than the control (NIP2). Furthermore, the MIP8 composite fiber membrane showed higher selectivity to PPL than the other β-blockers (atenolol, metoprolol, and timolol). Thus, the MIP8 composite fiber membrane can be further developed for various applications in pharmaceutical and other affinity separation fields.

Key words

membrane molecularly imprinted propranolol selective molecular imprinting 



The authors would like to acknowledge Commission of Higher Education (Thailand) and the Thailand Research Funds through the Golden Jubilee Ph.D. Program (grant no. PHD/0092/2554) and the Silpakorn University Research and development institute for the financial support (grant no. SURID55/02/12).


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Copyright information

© American Association of Pharmaceutical Scientists 2013

Authors and Affiliations

  • Prasopchai Tonglairoum
    • 1
  • Wanita Chaijaroenluk
    • 1
  • Theerasak Rojanarata
    • 1
  • Tanasait Ngawhirunpat
    • 1
  • Prasert Akkaramongkolporn
    • 1
  • Praneet Opanasopit
    • 1
  1. 1.Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of PharmacySilpakorn UniversityNakhon PathomThailand

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