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Study of the Potential of Amphiphilic Conetworks Based on Poly(2-ethyl-2-oxazoline) as New Platforms for Delivery of Drugs with Limited Solubility

Abstract

Thermoresponsive amphiphilic conetworks comprising poly(2-ethyl-2-oxazoline) (PEtOx), 2-hydroxyethyl methacrylate, and 2-hydroxypropyl acrylate segments have been studied as new platforms for delivery of drug with limited solubility. Series of conetworks of varied composition were synthesized and swelling kinetics in aqueous media and ethanol were followed. The platforms were loaded with the hydrophobic drug ibuprofen by swelling in its ethanol solution. The structure and properties of the drug carriers were investigated by scanning electron microscopy and differential scanning calorimetry. The release kinetics profiles of ibuprofen from the studied platform were established. The investigation proved the feasibility of the PEtOx-based amphiphilic conetworks as highly effective platforms for sustained ibuprofen delivery.

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ACKNOWLEDGMENTS

Financial support by National Science Fund of Bulgaria (Project UNION, Grant # DCVP 02/2/2009) is gratefully acknowledged.

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Correspondence to Darinka Christova.

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Kostova, B., Ivanova-Mileva, K., Rachev, D. et al. Study of the Potential of Amphiphilic Conetworks Based on Poly(2-ethyl-2-oxazoline) as New Platforms for Delivery of Drugs with Limited Solubility. AAPS PharmSciTech 14, 352–359 (2013). https://doi.org/10.1208/s12249-013-9923-7

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  • DOI: https://doi.org/10.1208/s12249-013-9923-7

Key words

  • amphiphilic conetworks
  • drug delivery systems
  • polyoxazolines
  • termoresponsive polymers