AAPS PharmSciTech

, Volume 13, Issue 1, pp 174–183 | Cite as

Solubility-Modulated Asymmetric Membrane Tablets of Triprolidine Hydrochloride: Statistical Optimization and Evaluation

Research Article

Abstract

The aim of the present study was to develop asymmetric membrane (AM) tablets for controlled delivery of highly water-soluble antihistaminic drug triprolidine hydrochloride. The solubility of triprolidine hydrochloride was modulated through the incorporation of coated sodium chloride crystals encapsulated with asymmetric membrane coating polymer, cellulose acetate butyrate. Formulation of AM tablets was based on a 23 factorial design to study the effect of formulation variables, namely, polymer concentration, level of pore former, and amount of osmogen on the in vitro release. Core tablets prepared by wet granulation and coated with asymmetric membrane by a dip coating method were evaluated. Statistical analysis was done with the Design Expert Software 8.0.2 (USA), and the polynomial equation generated by Pareto charts was used for validation of the experimental design. The interaction chart and response surface plots deduced the simultaneous effect of independent variables on in vitro drug release. The in vitro drug release was inversely proportional and directly related to the level(s) of polymer and pore former in the membrane, respectively. The level of osmogen not only increased the osmotic pressure but also controlled the drug release due to a common ion effect. The drug release of the optimized formulation (F6) followed zero-order kinetics, which would be capable of reducing the administration, and was stable over 3 months. SEM photographs revealed asymmetry in membrane structure.

KEY WORDS

asymmetric membrane coated sodium chloride cellulose acetate butyrate solubility modulation 23 factorial design 

Notes

ACKNOWLEDGMENTS

The authors are greatly thankful to the Indian Institute of Technology, New Delhi, India, for extending facilities for SEM for the characterization of asymmetric membrane and AICTE, India, for providing financial assistance to Mr. Rahul Dev.

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Copyright information

© American Association of Pharmaceutical Scientists 2011

Authors and Affiliations

  1. 1.Department of PharmaceuticsRajiv Academy for PharmacyMathuraIndia

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