Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization
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A new bioactive glass-based scaffold was developed for local delivery of drugs in case of osteomyelitis. Bioactive glass having a new composition was prepared and converted into porous scaffold. The bioactivity of the resulting scaffold was examined by in vitro acellular method. The scaffolds were loaded with two different drugs, an antibacterial or antifungal drug. The effects of the size of the scaffold, drug concentration, and dissolution medium on drug release were studied. The scaffolds were further coated with a degradable natural polymer, chitosan, to further control the drug release. Both the glass and scaffold were bioactive. The scaffolds released both the drugs for 6 weeks, in vitro. The results indicated that the bigger the size and the higher the drug concentration, the better was the release profile. The scaffolds appeared to be suitable for local delivery of the drugs in cases of osteomyelitis.
Key wordsbioceramics bone infection drug release organic–inorganic composite skeletal drug delivery
The authors wish to express their sincere thanks to The Director, CG&CRI, India for the kind permission and support for the successful completion of the research work. All the departments and technical staffs involved in characterization are duly acknowledged.
- 4.Ouedraogo M, Semde R, Some IT, Traore-Ouedraogo R, Guissou IP, Henschel V, et al. Monoolein–water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization. Drug Dev Ind Pharm. 2008;34:753–60.CrossRefPubMedGoogle Scholar
- 5.Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, et al. Development of new localized drug delivery system based on ceftriaxone–sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial. Pharm Res. 2010;27:1659–76.CrossRefPubMedGoogle Scholar
- 11.Bang H-G, Kim S-J, Park S-Y. Biocompatibility and the physical properties of bio-glass ceramics in the Na2O–CaO–SiO2–P2O5 system with CaF2 and MgF2 additives. J Ceram Process Res. 2008;9:588–90.Google Scholar
- 20.NCCLS. Performance standards for antimicrobial susceptibility testing. Wayne: NCCLS; 2002.Google Scholar