Various techniques for physical characterization of active pharmaceutical ingredients, including X-ray powder diffraction, birefringence observation, Raman spectroscopy, and high-performance liquid chromatography, can be conducted using 96-well plates. The only exception among the important characterization items is the thermal analysis, which can be a limiting step in many cases, notably when screening the crystal/salt form. In this study, infrared thermal camera technology was applied for thermal characterization of pharmaceutical compounds. The melting temperature of model compounds was determined typically within 5 min, and the obtained melting temperature values agreed well with those from differential scanning calorimetry measurements. Since many compounds can be investigated simultaneously in this infrared technology, it should be promising for high-throughput thermal analysis in the pharmaceutical developmental process.
high-throughput analysis infrared camera thermal analysis
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The author would like to thank Apiste (Osaka, Japan) for the use of the infrared camera. This work was in part supported by World Premier International Research Center (WPI) Initiative on Materials Nanoarchitectonics, MEXT, Japan.
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