AAPS PharmSciTech

, Volume 11, Issue 2, pp 708–718 | Cite as

Development and Evaluation of Hydrophilic Colloid Matrix of Famotidine Tablets

  • Muhammad Harris Shoaib
  • Saniah Al Sabah Siddiqi
  • Rabia Ismail Yousuf
  • Kamran Zaheer
  • Muhammad Hanif
  • Saeed Rehana
  • Sabahat Jabeen
Research Article

Abstract

The objective of the present study was to develop a once-daily sustained-release (SR) matrix tablet of famotidine. Nine different formulations (F1–F9) were prepared by direct compression method using Avicel PH101 as filler/binder in the range of 41–27% in F1–F3, 18–22% in F4–F7, and 16–18% in F8–F9 and hydroxypropyl methylcellulose (4,000 cps) as hydrophilic matrix was used in F1–F3 from 19% to 30%, around 40% in F4–F7, and 42–45% in F8–F9. Talc and Aerosil were added in the ratio of 0.7–1.2%. The tablets were subjected to various physical parameters including weight variation test, hardness, thickness, diameter, friability, and in vitro release studies. Assay was also performed according to the USP 30 NF 25 procedure. The results of the physical parameters and assay were found to be within the acceptable range. In vitro dissolution results indicated that formulation F4–F7, having around 40% of rate control polymer, produced a SR pattern throughout 24 h. F1–F3 showed drug release at a faster rate, while F8–F9 released much slower, i.e., <80% in 24 h. Model-dependent and model-independent methods were used for data analysis and the best results were observed for F4 in zero order (r 2 = 0.984) and F6 in Korsmeyer and Higuchi (r 2 = 0.992 and 0.988). The parameter n indicated anomalous diffusion, while β in Weibull showed a parabolic curve with higher initial slope. The f 2 similarity test was performed taking F4 as a reference formulation. Only the F5–F7 formulations were similar to the reference formulation F4. The mean dissolution time was around 10 h for the successful formulation.

Key words

famotidine hydrophilic colloid matrix hydroxypropyl methylcellulose (HPMC) kinetics sustained release 

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Copyright information

© American Association of Pharmaceutical Scientists 2010

Authors and Affiliations

  • Muhammad Harris Shoaib
    • 1
  • Saniah Al Sabah Siddiqi
    • 2
  • Rabia Ismail Yousuf
    • 1
  • Kamran Zaheer
    • 3
  • Muhammad Hanif
    • 1
  • Saeed Rehana
    • 1
  • Sabahat Jabeen
    • 1
  1. 1.Department of Pharmaceutics, Faculty of PharmacyUniversity of KarachiKarachiPakistan
  2. 2.Federal Urdu UniversityKarachiPakistan
  3. 3.Faculty of PharmacyHamdard UniversityKarachiPakistan

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