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AAPS PharmSciTech

, Volume 10, Issue 4, pp 1158–1171 | Cite as

Organic–Inorganic Composites for Bone Drug Delivery

  • Chidambaram Soundrapandian
  • Biswanath Sa
  • Someswar Datta
Mini-Review

Abstract

This review paper attempts to provide an overview in the fabrication and application of organic–inorganic based composites in the field of local drug delivery for bone. The concept of local drug delivery exists for a few decades. However, local drug delivery in bone and specially application of composites for delivery of drugs to bone is an area for potential research interest in the recent time. The advantages attained by an organic–inorganic composite when compared to its individual components include their ability to release drug, adopting to the natural environment and supporting local area until complete bone regeneration, which make them carriers of interest for local drug delivery for bone.

Key words

biomaterials carrier systems composite local delivery organic–inorganic 

Abbreviations

BG

Bioactive glass

BMP

Bone morphogenetic protein

CS

Calcium sulfate

DMC

Dimethyl carbonate

Hap

Hydroxyapatite

PCL

Polycaprolactone

PDLLA

Poly (d,l-lactide)

PHBV

Polyhydroxybutyrate-co-hydroxyvalerate

PLGA

Polylactide-co-glycolide

PMMA

Polymethylmethacrylate

rh

Recombinant human

SBF

Simulated body fluid

TCP

Tricalcium phosphate

TGF

Transforming growth factor

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Chidambaram Soundrapandian
    • 1
  • Biswanath Sa
    • 1
  • Someswar Datta
    • 2
  1. 1.Department of Pharmaceutical TechnologyJadavpur UniversityKolkataIndia
  2. 2.Bioceramic and Coating DivisionCentral Glass & Ceramic Research InstituteKolkataIndia

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