AAPS PharmSciTech

, 10:858 | Cite as

Studies on the Effect of Water-Soluble Polymers on Drug–Cyclodextrin Complex Solubility

  • Rajashree S. Hirlekar
  • Suneeta N. Sonawane
  • Vilasrao J. Kadam
Research Article

Abstract

The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodextrins in presence of different concentrations of water-soluble polymers (PEG 4000 and PVP K-90) on the dissolution rate of the drug has been investigated. Phase solubility studies were carried out to evaluate the solubilizing power of βCD in association with water-soluble polymers towards IRB and to determine the apparent stability constant (K S) of the complexes. Improvement in K S value for ternary complexes (IRB–βCD–polymers) clearly proved the benefit on the addition of water-soluble polymer to increase complexation efficiency. The dissolution rate of the drug from ternary systems containing PEG 4000 and PVP K-90 was higher as compared to the binary system. An optimum increase in the dissolution rate of the drug was observed at a polymer concentration of 5% w/w for PVP K-90 and 10% w/w for PEG 4000. DSC, FTIR, SEM, and XRD studies were carried out to characterize the complexes.

Key words

dissolution hydrophilic polymers irbesartan solubility β-cyclodextrin 

Abbreviations:

IRB

irbesartan

βCD

beta-cyclodextrins

DSC

differential scanning calorimetry

FTIR

Fourier transform infrared spectroscopy

XRD

X-ray diffraction

SEM

scanning electron microscopy

KS

apparent stability constant

CE

co-evaporation

HCl

hydrochloric acid

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Rajashree S. Hirlekar
    • 1
  • Suneeta N. Sonawane
    • 1
  • Vilasrao J. Kadam
    • 1
  1. 1.Department of PharmaceuticsBharati Vidyapeeth’s College of PharmacyNavi MumbaiIndia

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