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AAPS PharmSciTech

, Volume 10, Issue 2, pp 631–640 | Cite as

Preparation and In Vitro Evaluation of Solid Dispersions of Total Flavones of Hippophae rhamnoides L.

  • Yan Xie
  • Guowen Li
  • Xiurong Yuan
  • Zhenzhen Cai
  • Rong Rong
Research Article

Abstract

The purpose of this study was to enhance the dissolution of total flavones of Hippophae rhamnoides L. (TFH) by solid dispersions consisting of the drug and a polymeric carrier, poloxamer 188 (PXM). The solvent evaporation method was used to prepare solid dispersions. A 32 full-factorial design approach was used for optimization wherein the amount of solvent (X 1) and the drug-to-polymer ratio (X 2) were selected as independent variables and the percentage of TFH dissolved in 10 min (Q 10) was selected as the dependent variable. Multiple linear regression analysis revealed that a suitable level of X 1 and X 2 was required for obtaining higher dissolution of TFH from PXM solid dispersions. Solid dispersions were characterized by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and dissolution tests. Characterization studies revealed that solid dispersion of TFH–PXM showed enhancement of TFH dissolution due to the conversion of TFH into a less crystalline and/or amorphous form. In conclusion, dissolution enhancement of TFH was obtained by preparing its solid dispersions in PXM using solvent method.

Key words

poloxamer 188 solid dispersions solvent method total flavones of Hippophae rhamnoides

Notes

Acknowledgment

This work was supported by the Shanghai City College Scientific Research Fund for Choosing and Cultivating Excellent Youth Teacher of China (szy-07034). The authors are grateful to Vice-professor Yue Su for her instruction on the statistics analysis, Ms. Fuyuan Ye for her FTIR and X-ray recording, and Mr. Jun Li for his DSC recording.

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Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Yan Xie
    • 1
  • Guowen Li
    • 1
  • Xiurong Yuan
    • 1
  • Zhenzhen Cai
    • 1
  • Rong Rong
    • 1
  1. 1.Shanghai University of Traditional Chinese Medicine, Science and Technology CenterShanghaiPeople’s Republic of China

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