AAPS PharmSciTech

, Volume 10, Issue 1, pp 266–269 | Cite as

Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery

  • Fífa Konrádsdóttir
  • Helga Ogmundsdóttir
  • Valgardur Sigurdsson
  • Thorsteinn Loftsson
Brief/Technical Note

Key words

cyclodextrin curcumin dermal hair hair follicles skin 

References

  1. 1.
    V. M. Meidan, M. C. Bonner, and B. B. Michniak. Transfollicular drug delivery—Is it a reality? Int. J. Pharm. 306:1–14 (2005).PubMedCrossRefGoogle Scholar
  2. 2.
    A. Vogt, N. Mandt, J. Lademann, H. Schaefer, and U. Blume-Peytavi. Follicular targeting—A promising tool in selective dermatotherapy. J. Invest. Dermatol. Symp. Proc. 10:252–255 (2005).CrossRefGoogle Scholar
  3. 3.
    S. Jung, N. Otberg, G. Thiede, H. Richter, W. Sterry, S. Panzner, and J. Lademann. Innovative liposomes as a transfollicular dru delivery system: Penetration into porcine hair follicles. J. Invest. Dermatol. 126:1728–1732 (2006).PubMedCrossRefGoogle Scholar
  4. 4.
    J. Lademann, H. Richter, A. Teichmann, N. Otberg, U. Blume-Peytavi, J. Luengo, B. Weiß, U. F. Schaefer, C.-M. Lehr, R. Wepf, and W. Sterry. Nanoparticles—An efficient carrier for drug delivery to the hair follicles. Eur. J. Pharm. Biopharm. 66:159–164 (2007).PubMedCrossRefGoogle Scholar
  5. 5.
    N. Otberg, A. Patzelt, U. Rasulev, T. Hagemeister, M. Linscheid, R. Sinkgraven, W. Sterry, and J. Lademann. The role of hair follicles in the percutaneous absorption of caffeine. Br. J. Clin. Pharmacol. 65:488–492 (2007).PubMedCrossRefGoogle Scholar
  6. 6.
    J. Lademann, H.-J. Weigmann, C. Rickmeyer, H. Barthelmes, H. Schaefer, G. Mueller, and W. Sterry. Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 12:247–256 (1999).PubMedGoogle Scholar
  7. 7.
    T. Loftsson, P. Jarho, M. Másson, and T. Järvinen. Cyclodextrins in drug delivery. Expert Opin. Drug Deliv. 2:335–351 (2005).PubMedCrossRefGoogle Scholar
  8. 8.
    T. Loftsson, and D. Duchêne. Cyclodextrins and their pharmaceutical applications. Int. J. Pharm. 329:1–11 (2007).PubMedCrossRefGoogle Scholar
  9. 9.
    P. Tomasik, and C. H. Schilling. Complexes of starch with inorganic guests. In D. Horton (eds.), Advances in Carbohydrate Chemistry and Biochemistry, Vol 53, Academic, San Diego, 1998, pp. 263–343.CrossRefGoogle Scholar
  10. 10.
    P. Tomasik, and C. H. Schilling. Complexes of starch with organic guests. In D. Horton (eds.), Advances in Carbohydrate Chemistry and Biochemistry, Vol 53, Academic, San Diego, 1998, pp. 345–426.CrossRefGoogle Scholar
  11. 11.
    T. Loftsson, H. Fridriksdottir, and T. K. Gudmundsdottir. The effect of water-soluble polymers on aqueous solubility of drugs. Int. J. Pharm. 127:293–296 (1996).CrossRefGoogle Scholar
  12. 12.
    T. Loftsson, M. Másson, and M. E. Brewster. Self-association of cyclodextrins and cyclodextrin complexes. J. Pharm. Sci. 93:1091–1099 (2004).PubMedCrossRefGoogle Scholar
  13. 13.
    M. Bonini, S. Rossi, G. Karlsson, M. Almgren, P. Lo Nostro, and P. Baglioni. Self-assembly of β-cyclodextrin in water. Part 1: Cryo-TEM and dynamic and static light scattering. Langmuir. 22:1478–1484 (2006).PubMedCrossRefGoogle Scholar
  14. 14.
    W. He, P. Fu, X. H. Shen, and H. C. Gao. Cyclodextrin-based aggregates and characterization by microscopy. Micron. 39:495–516 (2008).PubMedCrossRefGoogle Scholar
  15. 15.
    T. Loftsson, K. Matthíasson, and M. Másson. The effects of organic salts on the cyclodextrin solubilization of drugs. Int. J. Pharm. 262:101–107 (2003).PubMedCrossRefGoogle Scholar
  16. 16.
    F. B. De Sousa, A. M. Leite Deadai, I. S. Lula, C. S. Nascimento, N. S. G. Fernandes Neto, A. C. Lima, W. B. De Almeida, and R. D. Sinisterra. Supramolecular self-assembly of cyclodextrin and higher water soluble guest: Thermodynamics and topological studies. J. Am. Chem. Soc. 130:8426–8436 (2008).PubMedCrossRefGoogle Scholar
  17. 17.
    H. H. Tønnesen, M. Másson, and T. Loftsson. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability. Int. J. Pharm. 244:127–135 (2002).PubMedCrossRefGoogle Scholar
  18. 18.
    N. Otberg, H. Richter, H. Schaefer, U. Blume-Peytavi, W. Sterry, and J. Lademann. Visualization of topically applied fluorescent dyes in hair follicles by laser scanning microscopy. Laser Phys. 13:761–764 (2003).Google Scholar
  19. 19.
    U. Jacobi, E. Waibler, W. Sterry, and J. Lademann. In vivo determination of the long-term reservoir of the horny layer using laser scanning microscopy. Laser Phys. 15:565–569 (2005).Google Scholar
  20. 20.
    H. J. J. Pabon. A synthesis of curcumin and related compounds. Rec. Trav. Chim. Pays-Bas. 83:379–386 (1964).Google Scholar
  21. 21.
    U. Jacobi, T. Tassopoulos, C. Surber, and J. Lademann. Cutaneous distribution and localization of dyes affected by vehicles all with different lipophilicity. Arch. Dermatol. Res. 297:303–310 (2006).PubMedCrossRefGoogle Scholar
  22. 22.
    A. Teichmann, S. Heuschkel, U. Jacobi, G. Presse, R.H.H. Neubert, W. Sterry, and J. Lademann. Comparison of stratum corneum penetration and localization of lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur. J. Pharm. Biopharm. 67:699–706 (2007).PubMedCrossRefGoogle Scholar
  23. 23.
    T. Loftsson, S.B. Vogensen, M.E. Brewster, and F. Konráðsdóttir. Effects of cyclodextrins on drug delivery through biological membranes. J. Pharm. Sci. 96:2532–2546 (2007).PubMedCrossRefGoogle Scholar
  24. 24.
    M. E. Brewster, M. Noppe, J. Peeters, and T. Loftsson. Effect of the unstirred water layer on permeability enhancement by hydrophilic cyclodextrins. Int. J. Pharm. 342:250–253 (2007).PubMedCrossRefGoogle Scholar
  25. 25.
    R. Y. Anadolu, T. Sen, N. Tarimci, A. Birol, and C. Erdem. Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex ψ. J. Eur. Acad. Dermatol. Venereol. 18:416–421 (2004).PubMedCrossRefGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2009

Authors and Affiliations

  • Fífa Konrádsdóttir
    • 1
  • Helga Ogmundsdóttir
    • 2
  • Valgardur Sigurdsson
    • 2
  • Thorsteinn Loftsson
    • 1
  1. 1.Faculty of Pharmaceutical SciencesUniversity of IcelandReykjavikIceland
  2. 2.Faculty of MedicineUniversity of IcelandReykjavikIceland

Personalised recommendations