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AAPS PharmSciTech

, Volume 9, Issue 2, pp 342–348 | Cite as

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

  • H. Yeşim Karasulu
  • Z. Evren Şanal
  • Sumru Sözer
  • Tamer Güneri
  • Gökhan Ertan
Research Article

Abstract

The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes (nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND, intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as an alternative to intravenous and per oral administrations of IND to overcome their adverse effects.

Key words

anti-inflammatory activity indomethacin nasal emulsion penetration enhancer 

Notes

Acknowledgements

This study was supported by Research Foundation of Ege University. The authors would like to thank Pınar Integrated Meat and Flour Inc. for providing the sheep nasal mucosa in performing the ex vivo studies.

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Copyright information

© American Association of Pharmaceutical Scientists 2008

Authors and Affiliations

  • H. Yeşim Karasulu
    • 1
  • Z. Evren Şanal
    • 1
  • Sumru Sözer
    • 2
  • Tamer Güneri
    • 1
  • Gökhan Ertan
    • 1
  1. 1.Department of Pharmaceutical Technology, Faculty of PharmacyUniversity of EgeBornovaTurkey
  2. 2.Department of Pharmaceutical Toxicology, Faculty of PharmacyUniversity of EgeBornovaTurkey

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