AAPS PharmSciTech

, Volume 8, Issue 3, pp E195–E202 | Cite as

Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

  • Carla Martins Lopes
  • José M. Sousa Lobo
  • João F. Pinto
  • Paulo C. Costa


The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (⊂16 or >24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.


Biphasic delivery system dual-component tablet 


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Copyright information

© American Association of Pharmaceutical Scientists 2007

Authors and Affiliations

  • Carla Martins Lopes
    • 1
  • José M. Sousa Lobo
    • 1
  • João F. Pinto
    • 2
  • Paulo C. Costa
    • 1
  1. 1.Departmento de Tecnologia Farmacêutica, Faculdade de FarmáciaUniversidade do PortoPortoPortugal
  2. 2.Departmento de Tecnologia Farmacêutica, Faculdade de FarmáciaUniversidade de LisboaLisboaPortugal

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