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AAPS PharmSciTech

, Volume 8, Issue 1, pp E118–E123 | Cite as

Suppression of agglomeration of ciprofloxacin-loaded human serum albumin nanoparticles

  • P. Vijayaraj Kumar
  • Narendr K. Jain
Article

Abstract

The present study is aimed at developing and exploring the use of pectin in suppression of agglomeration of ciprofloxacinloaded human serum albumin (HSA) nanoparticles. The HSA-pectin nanoparticles loaded with ciprofloxacin were prepared by the pH-coacervation method, and various physicochemical parameters such as particle size, morphology, ζ-potential, electrolyte-induced flocculation, pH-dependent ζ-potential, drug loading, in vitro drug release, and stability of nanoparticles, were evaluated. The size of the HSA-pectin nanoparticles (F3) was found to be 180 to 290 nm. The HSA nanoparticles were modified with pectin when the critical flocculation concentration of nanoparticles in Na2SO4 solution was increased from 0.3 M to 0.9 M. The isoelectric points of the formed nanoparticles were found to be relatively lower between pH values 3 and 6. Pectin may be used as a pharmaceutical additive for the suppression of particle agglomeration in HSA nanoparticles, and the effect may be attributed to the pectin segments present on the surface of nanoparticles.

Keywords

Ciprofloxacin human serum albumin pectin nanoparticles agglomeration 

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Copyright information

© American Association of Pharmaceutical Scientists 2007

Authors and Affiliations

  1. 1.Pharmaceutics Research Laboratory, Department of Pharmaceutical SciencesDr Hari Singh Gour UniversitySAGARIndia

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