AAPS PharmSciTech

, Volume 6, Issue 3, pp E367–E371 | Cite as

Optimization of tablets containing a high dose of spray-dried plant extract: A technical note

  • Luiz Alberto Lira Soares
  • George González Ortega
  • Pedro Ros Petrovick
  • Peter Christian Schmidt


Optimization of CSD and CMC-Na in tablet formulations containing a high dose of SDE fromM ilicifolia was performed by central composite design (CCD) and response surface methodology (RSM). The study demonstrated that CSD affected mainly the hardness and friability, while CMC-Na modified the disintegration times. The optimum formula for minimum disintegration time and friability, and maximum crushing strength, was found to contain 1.2% (wt/wt) of CSD and 5.0% (wt/wt) of CMC-Na. At these conditions, the tablet shows a crushing strength of 107.9 N, a friability of 0.56% (wt/wt), and a maximum disintegration time of 6.8 minutes.


Tablets optimization central composite design spray-dried extract Maytenus ilicifolia 


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Copyright information

© American Association of Pharmaceutical Scientists 2005

Authors and Affiliations

  • Luiz Alberto Lira Soares
    • 1
    • 2
  • George González Ortega
    • 2
  • Pedro Ros Petrovick
    • 2
  • Peter Christian Schmidt
    • 3
  1. 1.Departamento de FarmáciaUFRNNatalBrazil
  2. 2.Programa de Pós-Graduação em Ciências FarmacêuticasUFRGSPorto AlegreBrazil
  3. 3.Department of Pharmaceutical TechnologyUniversity of TübingenTübingenGermany

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