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Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method

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Abstract

The purpose of this study was to outline the effects of interactions between a model drug and various acrylic polymers on the physical properties of nanoparticles prepared by an aerosol flow reactor method. The amount of model drug, ketoprofen, in the nanoparticles was varied, and the nanoparticles were analyzed for particle size distribution, particle morphology, thermal properties, IR spectroscopy, and drug release. The nanoparticles produced were spherical, amorphous, and had a matrix-type structure. Ketoprofen crystallization was observed when the amount of drug in Eudragit L nanoparticles was more than 33% (wt/wt). For Eudragit E and Eudragit RS nanoparticles, the drug acted as an effective plasticizer resulting in lowering of the glass transition of the polymer. Two factors affected the preparation of nanoparticles by the aerosol flow reactor method, namely, the solubility of the drug in the polymer matrix and the thermal properties of the resulting drug-polymer matrix.

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Author notes

  1. Hannele Eerikäinen

    Present address: Pharmaceutical Product Development, Orion Corporation Orion Pharma, PO Box 65, FIN-02101, Espoo, Finland

Authors and Affiliations

  1. Center for New Materials, Helsinki University of Technology, PO Box 1602, FIN-02044, VTT, Finland

    Hannele Eerikäinen, Janne Raula & Esko I. Kauppinen

  2. Faculty of Pharmacy and Viikki Drug Discovery Center, University of Helsinski, PO Box 56, FIN-00014, Helsinki, Finland

    Leena Peltonen & Jouni Hirvonen

  3. Aerosol Technology Group, VTT Processes, PO Box 1602, FIN-02044, VTT, Finland

    Esko I. Kauppinen

Authors
  1. Hannele Eerikäinen
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  2. Leena Peltonen
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  3. Janne Raula
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  4. Jouni Hirvonen
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  5. Esko I. Kauppinen
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Correspondence to Esko I. Kauppinen.

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Eerikäinen, H., Peltonen, L., Raula, J. et al. Nanoparticles containing ketoprofen and acrylic polymers prepared by an aerosol flow reactor method. AAPS PharmSciTech 5, 68 (2004). https://doi.org/10.1208/pt050468

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  • DOI: https://doi.org/10.1208/pt050468

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