Effect of hydroxypropyl methylcellulose and hydrogenated castor oil on naproxen release from sustained-release tablets
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The effect of the concentration of hydrophilic (hydroxypropyl methylcellulose [HPMC]) and hydrophobic (hydrogenated castor oil [HCO]) products, fillers (lactose and dibasic calcium phosphate), and buffers (sodium bicarbonate, calcium carbonate, and sodium citrate) on naproxen release rate was studied. Matrix tablets were prepared by double compression, andIn vitro dissolution tests were performed. The dissolution results showed that an increased amount of HPMC or hydrogenated castor oil resulted in reduced drug release. The inclusion of buffers in the HPMC matrix tablets enhanced naproxen release. For HCO tablets, only sodium bicarbonate enhanced naproxen release. The presence of lactose on HPMC matrix tablets did not show a significantly different result from that obtained with the formulation containing dibasic calcium phosphate as a filler. However, for the tablets containing HCO, the presence of lactose significantly enhanced the naproxen release rate. The matrix-forming materials in this study were suitable for use in sustained-release tablets containing naproxen. The drug release can be modulated by adding suitable amounts of diluents and buffers.
KeywordsNaproxen Sustained-release Hydrophilic matrix Lipidic matrix
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- 1.Todd PA, Clissold SP. Naproxen: a reappraisal of its pharmacology, and use in rheumatic diseases and pain states.Drugs. 1990;40:91–137.Google Scholar
- 4.Kibbe AHandbook of Pharmaceutical Excipients. Washington: American Pharmaceutical Association and The Pharmaceutical Society of Great Britain; 1986:49–50.Google Scholar
- 5.Lachman L, Lieberman HA, Kanig JL.Pharmaceutical Dosage Forms-Tablets. 2nd ed. Vol 1. New York: marcel Dekker Inc; 1989:13.Google Scholar
- 6.Zecchi V, Rodriguez L, Tartarini A, Chiarini A, Valenti P.In vitro absorption studies on naproxen and its sodium and piperazine salts.Pharm Acta Helv. 1984;59:91–94.Google Scholar
- 7.US Pharmacopoeia XXIII. Rockville, MD: US Pharmacopeial Convention; 1995:1054.Google Scholar
- 9.European Pharmacopeia. 3rd ed. Council of Europe, Strasbourg; 1997:133–135.Google Scholar
- 10.Morgan S, Preston CL, Timmins P, melia CD. An investigation into the effect of citrate buffering on pH-dependent drug release, hydration and gel layer growth in HPMC matrices.Proceedings of the 18th Pharmaceutical Technology Conference. 1999;2:24–32.Google Scholar