Prediction of adsorption from multicomponent solutions by activated carbon using single-solute parameters
- 231 Downloads
The adsorption of 3 barbiturates—phenobarbital, mephobarbital, and primidone—from simulated intestinal fluid (SIF), without pancreatin, by activated carbon was studied using the rotating bottle method. The concentrations of each drug remaining in solution at equilibrium were determined with the aid of a high-performance liquid chromatography (HPLC) system employing a reversed-phase column. The competitive Langmuir-like model, the modified competitive Langmuir-like model, and the LeVan-Vermeulen model were each fit to the data. Excellent agreement was obtained between the experimental and predicted data using the modified competitive Langmuir-like model and the LeVan-Vermeulen model. The agreement obtained from the original competitive Langmuir-like model was less satisfactory. These observations are not surprising because the competitive Langmuir-like model assumes that the capacities of the adsorbates are equal, while the other 2 models take into account the differences in the capacities of the components.
The results of these studies indicate that the adsorbates employed are competing for the same binding sites on the activated carbon surface. The results also demonstrate that it is possible to accurately predict multicomponent adsorption isotherms using only single-solute isotherm parameters. Such prediction is likely to be useful for improving in vivo/in vitro correlations.
KeywordsMulticomponent Adsorption Activated Carbon Barbiturate Adsorption Prediction
Unable to display preview. Download preview PDF.
- 1.Andersen AH. Experimental studies on the pharmacology of activated charcoal. III. Adsorption from gastro-intestinal contents.Acta Pharmacol. 1948;4:275–284.Google Scholar
- 2.Nagami H, Nagai T, Uchida H. Physico-chemical approach to biopharmaceutical phenomena. V. Relationship between the adsorption by carbon black from aqueous solution and the biopharmaceutical data of barbituric acid derivatives.Chem Pharm Bull. 1969;17:176–180.Google Scholar
- 3.Huang L-F. [Ph.D. thesis].Determination of the Heats of Displacement for Various Barbituric Acid Derivatives on Two Activated Charcoals. Iowa City, IA: University of Iowa; 1993.Google Scholar
- 4.Burke GM. [Ph.D. thesis].Adsorptivity and Surface Characterization of Activated Charcoals. Iowa City, IA: University of Iowa; 1991.Google Scholar
- 5.The Merck Index. 12th ed. Whitehouse Station, NJ: Merck and Co., Inc.,; 1996.Google Scholar
- 7.Schwab GM.Theoretische und experimentelle Fortschritte auf dem Gebiete der heterogenen Gasreaktionen. Ergebnisse der Exakten Naturwissenschaften. Vol. 7. Berlin: Springer; 1928:276–341.Google Scholar
- 10.Young DM, Crowell AD. In:The Adsorption of Gas Mixtures. Washington, DC: Butterworths, Inc.; 1962:373–377.Google Scholar
- 12.Jain JS, Snoeyink VL. Adsorption from bisolute systems on active carbon.J WPCF. 1973;45(12):2463–2479.Google Scholar
- 16.Fritz W, Merk W, schlünder EU, Sontheimer H. In: Suffet IH, McGuire MJ, eds.Activated Carbon Adsorption of Organics from the Aqueous Phase. Vol. 1. Ann Arbor, MI: Ann Arbor Science Publishers, Inc.; 1980:193–195.Google Scholar
- 18.Singer PC, Yen C-Y. In: Suffet IH, McGuire MJ, eds.Activated Carbon Adsorption of Organics from the Aqueous Phase. Vol. 1. Ann Arbor, MI: Ann Arbor Science Publishers, Inc.; 1980:167–189.Google Scholar
- 24.Alkhamis KA. [Ph.D. thesis].Prediction of the Adsorption Isotherm Parameters of Various Barbituric Acid Derivatives and Diazepam by Activated Carbon. Iowa City, IA: University of Iowa; 1997.Google Scholar
- 26.Adamson AW. Solid Liquid Interface In:Physical Chemistry of Surfaces. 5th ed. New York: John Wiley and Sons; 1990:425.Google Scholar