Properties of microcrystalline cellulose and powder cellulose after extrusion/spheronization as studied by fourier transform Raman spectroscopy and environmental scanning electron microscopy
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In this study, the effect of powder cellulose (PC) and 2 types of microcrystalline cellulose (MCC 101 and MCC 301) on pellet properties produced by an extrusion/spheronization process was investigated. The different investigated types of cellulose displayed different behavior during the extrusion/spheronization process. Pure PC was unsuitable for extrusion, because too much water was required and the added water was partly squeezed during the extrusion process. In contrast, MCC 101 and MCC 301 were extrudable at a wide range of water content, but the quality of the resulting products varied. In the extrusion/spheronization process, MCC 101 was the best substance, with easy handling and acceptable product properties. The properties of the extrudates and pellets were determined by Fourier transform (FT) Raman spectroscopy and environmental scanning electron microscopy (ESEM). FT-Raman spectroscopy was able to distinguish between the original substances and also between the wet and dried extrudates. The particle sizes of the raw material and of the extrudates were determined by ESEM without additional preparation. For MCC, the size of the resulting particles within the extrudate or pellet was smaller. However, in the extrudates of PC, changes in particle size could not be observed.
Keywordspowder cellulose microcrystalline cellulose pellet Raman spectroscopy environmental scanning electron microscopy extrusion/spheronization
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- 1.Wallace JW. Cellulose derivatives and natural products utilized in pharmaceutics. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. New York, NY: Marcel Dekker; 1991;319–337.Google Scholar
- 2.Newton JM. Extrusion and extruders. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. New York, NY: Marcel Dekker; 2002;1220–1236.Google Scholar
- 5.Hopfe J, Füting M. Fundamentals and applications of environmental scanning electron microscopy. In: Wetzig K, Schulze D, eds. In Situ Scanning Electron Microscopy in Materials Research. Berlin, Germany: Akademie Verlag GmbH; 1995:219–240.Google Scholar
- 7.Dietrich R. Food technology transfers to pellet production. Manuf Chemist. 1989;60; Aug: 29–33.Google Scholar
- 12.Kleinebudde P, Jumaa M, Saleh FE. Influence of degree of polymerization on behavior of cellulose during homogenization and extrusion/spheronization. AAPS PharmSci. 2000;2(2) article 21.Google Scholar
- 15.Kristensen J, Schaefer T, Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements, II: effect of changes in the content of microcrystalline cellulose. AAPS PharmSci. 2000;2(3) article 24.Google Scholar
- 16.MacRitchie KA, Newton JM, Rowe RC. The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization. Eur J Pharm Sci. 2002;17:43–50.PubMedCrossRefGoogle Scholar
- 19.Saleh FE, Jumaa M, Hassan I, Kleinebudde P. Influence of cellulose type on the properties of extruded pellets. II: production and properties of pellets. STP Pharm Sci. 2000;10(5):379–385.Google Scholar