AAPS PharmSci

, Volume 4, Issue 1, pp 19–26 | Cite as

Protein binding predictions in infants



Plasma binding protein levels are lower in the newborn than in the adult and gradually increase with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (75%–80%), while alpha 1-acid glycoprotein (AAG) is initially half the adult concentration. As a result, the extent of drug binding to HSA is closer to that of the adult than are those drugs bound largely to AAG. A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children.


plasma protein binding fraction unbound infants children newborn albumin alpha 1-acid glycoprotein 


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© American Association of Pharmaceutical Scientists 2002

Authors and Affiliations

  1. 1.Division of Pharmaceutical Sciences, College of PharmacyUniversity of KentuckyLexington

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