A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes
Elastic liposoxy1mes (ELs) are biocompatible bilayer vesicular systems commonly used in the transdermal delivery of drugs. Compared with conventional liposomes (CLs), the strong deformation ability conferred by edge activators (EAs) is one of the most critical properties of ELs. However, due to limited research methods, little is known about the effect of EAs on the deformation abilities of vesicles. In this study, taking sodium cholate as an example, a multiscale study was carried to study the effect of EAs on the deformability of ELs, including in vitro diffusion experiment at macroscale, “vesicle-pore” model experiment at the microscale and flat patch model experiment at the molecular scale. As a result, it was found that sodium cholate could decrease the kc of DPPC bilayer, which enabled it to remain morphologically intact during a strong deformation process. Such kind of differences on deformation ability made pogostone ELs (contain sodium cholate) present a better permeation effect compared with that of pogostone CLs. All of these provide a multiscale and thorough understanding of the effect of sodium cholate on the deformation ability of ELs.
KeywordsDeformation ability Elastic liposomes Transdermal drug delivery "Vesicle-pore" model Sodium cholate
The content is solely the responsibility of the authors and does not necessarily represent the official views of the Beijing Natural Science Foundation. All simulations were performed at the National Supercomputer Center in Guangzhou.
This work was financially supported by the Beijing Natural Science Foundation (7162122).
- 16.Alvi IA, Madan J, Kaushik D, Sardana S, Pandey RS, Ali A. Comparative study of transfersomes, liposomes, and niosomes for topical delivery of 5-fluorouracil to skin cancer cells: preparation, characterization, in-vitro release, and cytotoxicity analysis. Anti-Cancer Drugs. 2011;22(8):774–82.CrossRefGoogle Scholar
- 31.Ma L, Wu Z, Yang C, Guo S, Chen L, Qiao Y, et al. Preparation and quaility evaluation of pogostone transfersomes. China Pharmacy. 2019;30(01):50–4.Google Scholar
- 33.Wang X, Zou Y, Wang Y. GC-MS assay for the determination of pogostone in essential oil of herba pogostemis. Chinese Journal of Pharmaceutical Analysis. 2005;30(5):546–9.Google Scholar
- 36.David VDS, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJC. GROMACS: fast, flexible, and free. J Comput Chem. 2010;26(16):1701–18.Google Scholar