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AAPS PharmSciTech

, 20:285 | Cite as

Sericin Inhibits Devitrification of Amorphous Drugs

  • Nitin Salunkhe
  • Namdeo JadhavEmail author
  • Harinath More
  • Prafulla Choudhari
Research Article

Abstract

The purpose of the present investigation was to analyze devitrification of amorphous drugs such as lornoxicam, meloxicam, and felodipine in the presence of sericin. The binary solid dispersions comprising varying mass ratios of drug and sericin were subject to amorphization by spray drying, solvent evaporation, ball milling, and physical mixing. Further, obtained solid dispersions (SDs) were characterized by HPLC, ATR-FTIR, H1NMR, molecular docking, accelerated stability study at 40°C and 75 ± 2% RH (XRD and DSC), and in vitro dissolution studies. The HPLC analysis indicated no decomposition of the drugs during the spray drying process. From ATR-FTIR, NMR, and molecular docking study, it was revealed that H-bonding played a vital role in amorphous drug stabilization. An excellent devitrification inhibition was observed in case of lornoxicam (SDLS3) and meloxicam (SDMS3) SDs prepared by spray drying. On the other hand, spray-dried SD of felodipine (SDFS3) showed traces of microcrystals. The percent crystallinity of SDLS3, SDMS3, and SDFS3 was found to be 7.4%, 8.23%, and 18.31% respectively indicating adequate amorphization. The dissolution performance of SDLS, SDMS, and SDFS after 3 months showed > 85% than SDs prepared by other methods. Thus, sericin significantly inhibited crystallization and was responsible for amorphous state stabilization of pharmaceuticals.

KEY WORDS

sericin devitrification amorphous solid dispersions (ASD) solubility dissolution 

Notes

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Nitin Salunkhe
    • 1
  • Namdeo Jadhav
    • 2
    Email author
  • Harinath More
    • 2
  • Prafulla Choudhari
    • 2
  1. 1.Department of PharmaceuticsAdarsh College of PharmacyVitaIndia
  2. 2.Department of PharmaceuticsBharati Vidyapeeth College of PharmacyKolhapurIndia

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