AAPS PharmSciTech

, 20:106 | Cite as

Solid Dispersion of Kaempferol: Formulation Development, Characterization, and Oral Bioavailability Assessment

  • Mariana Colombo
  • Gabriela de Lima Melchiades
  • Luana Roberta Michels
  • Fabrício Figueiró
  • Valquiria Linck Bassani
  • Helder Ferreira Teixeira
  • Letícia Scherer KoesterEmail author
Research Article


Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-inflammatory, and anticancer activity. However, this compound has low water solubility and hence poor oral bioavailability. This work aims to prepare a solid dispersion (SD) of KPF using Poloxamer 407 in order to improve the water solubility, dissolution rate, and pharmacokinetic properties KPF. After optimization, SDs were prepared at a 1:5 weight ratio of KPF:carrier using the solvent method (SDSM) and melting method (SDMM). Formulations were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) analysis, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The solubility in water of carried-KPF was about 4000-fold greater than that of free KPF. Compared with free KPF or the physical mixture, solid dispersions significantly increased the extent of drug release (approximately 100% within 120 min) and the dissolution rate. Furthermore, after oral administration of SDMM in rats, the area under the curve (AUC) and the peak plasma concentration (Cmax) of KPF from SDMM were twofold greater than those of free KPF (p < 0.05). In conclusion, SD with Poloxamer 407 is a feasible pharmacotechnical strategy to ameliorate the dissolution and bioavailability of KPF.


kaempferol Poloxamer 407 solid dispersion dissolution bioavailability 


Funding Information

This study was financially supported by CAPES-MEC, Brazil (Network Nanobiotec—grant no. 902/2009 and PROCAD—grant no. 552457/2011-6), CNPq (grant no. 453927/2014-9), and FAPERGS (Edital PqG 2017-T.O. 17/2551-0001043-4 and 17/2551-0000 970-3). M.C. thanks CAPES for her scholarship.


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Mariana Colombo
    • 1
  • Gabriela de Lima Melchiades
    • 1
  • Luana Roberta Michels
    • 1
  • Fabrício Figueiró
    • 2
    • 3
  • Valquiria Linck Bassani
    • 1
  • Helder Ferreira Teixeira
    • 1
  • Letícia Scherer Koester
    • 1
    Email author
  1. 1.Laboratório de Desenvolvimento Galênico, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de FarmáciaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  3. 3.Departamento de Bioquímica, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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