AAPS PharmSciTech

, 20:94 | Cite as

Assessing Aerosol Performance of a Dry Powder Carrier Formulation with Increasing Doses Using a Novel Inhaler

  • Stewart Yeung
  • Daniela Traini
  • Alan Tweedie
  • David Lewis
  • Tanya Church
  • Paul M. YoungEmail author
Research Article Theme: Paul Myrdal Memorial Issue - Pharmaceutical Formulation and Aerosol Sciences
Part of the following topical collections:
  1. Theme: Paul Myrdal Memorial Issue - Pharmaceutical Formulation and Aerosol Sciences


This study aims to investigate the implications of loaded formulation mass on aerosol performance using a reservoir novel dry powder inhaler containing a custom dosing cup to deliver carrier-based formulation to the lungs. A 3D printed dosing cup with volume size of 133.04 mm3 was manufactured to allow for the progressive loading of different carrier formulation masses of 1% beclomethasone dipropionate BDP (w/w) formulation (10 to 60 mg, with increments of 10 mg), in a novel customizable DPI device. Scanning electron micrographs were used to investigate BDP detachment from carrier particles post-aerosolisation and particle deposition on the USP induction port. The subsequent aerosol performance analysis was performed using the next generation impactor (NGI). Incrementally increasing the loading mass to 60 mg led to decreases in BDP detachment from carrier particles, resulting in significant decreases in aerosol performance. Increases in loading dose mass led to progressively decreased detachment of BDP from the carrier and the overall aerosol performance in comparison to the initial mass of 10 mg. These results are likely to be due to a decrease in void volume within the dosing cup with increased loading mass leading to altered airflow, decreased impaction forces and the possibility of a significant quantity of large carrier particles introducing a ‘sweeping’ effect on the inhaler inner surface. This study has shown that despite the decreased BDP detachment from the carrier and decreased aerosol performance, the dose delivered to the lung still increased due to the higher loaded dose.

Key Words

novel dry powder inhaler loading dose carrier formulation dispersion forces aerosol performance 



Australian Research Council ARC LP120200744.


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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Stewart Yeung
    • 1
  • Daniela Traini
    • 1
  • Alan Tweedie
    • 2
  • David Lewis
    • 2
  • Tanya Church
    • 2
  • Paul M. Young
    • 1
    • 3
    Email author
  1. 1.Respiratory Technology, the Woolcock Institute for Medical Research and Discipline of Pharmacology, Faculty of Medicine and HealthUniversity of SydneySydneyAustralia
  2. 2.Chiesi LimitedChippenhamUK
  3. 3.GlebeAustralia

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