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AAPS PharmSciTech

, 20:92 | Cite as

Recent Perspectives in Hot Melt Extrusion-Based Polymeric Formulations for Drug Delivery: Applications and Innovations

  • Yangmei Ren
  • Lan Mei
  • Liangxue Zhou
  • Gang GuoEmail author
Review Article

Abstract

Hot melt extrusion (HME), a technology which mixing the advantages of solid dispersion technology and mechanical preparation, is accepted in varied applications in pharmaceutical formulations. When combined with other techniques, such as nanotechnique, three-dimensional printing, and co-extrusion, HME becomes much more multifunctional in the application of drug delivery. While in most cases, polymers employed in HME are responsible for the final property of products. The process of HME together with the selection of materials employed in HME were described briefly. In addition, the applications of HME in drug delivery and its currently status in the pharmaceutical field were also included. Some commercial products produced by HME have met the approval of FDA, indicating the commercial viability of this technique. Although showing great potential in pharmaceutical manufacturing, HME is still challenged by high temperature, shear force, and high input energy. Development of equipment, modifying the parameters, and optimization of polymeric formulations are needed for a safe, effective, and multifunctional hot melt extrusion drug delivery system. Also, wider range of combinations between HME and other techniques may provide guideline for developing multiple applications in drug delivery.

KEY WORDS

hot melt extrusion three-dimensional printing nanotechnology drug delivery systems amorphous solid dispersion 

Notes

Funding Information

This work was financially supported by National Natural Sciences Foundation of China (81772693), National S&T Major Project (2011ZX09102-001-10 and 2015ZX09102010), Luzhou Science and Technology Plan (2018CDLZ-10), and Sichuan Provincial Administration of Traditional Chinese Medicine Support Project (2018JC021).

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© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Biotherapy and Cancer Center, and Department of NeurosurgeryWest China Hospital, Sichuan University, and Collaborative Innovation Center for BiotherapyChengduPeople’s Republic of China

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