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AAPS PharmSciTech

, 20:35 | Cite as

Development of Valsartan Floating Matrix Tablets Using Low Density Polypropylene Foam Powder: In vitro and In vivo Evaluation

  • Mohamed RahamathullaEmail author
  • S. Saisivam
  • H. V. Gangadharappa
Research Article
  • 107 Downloads

Abstract

The main purpose of the study was to develop valsartan floating tablets (VFT) via non-effervescent technique using low density polypropylene foam powder, carbopol, and xanthan gum by direct compression. Before compression, the particulate powdered mixture was evaluated for pre-compression parameters. The prepared valsartan tablets were evaluated for post-compression parameters, swelling index, floating lag time, in vitro buoyancy studies, and in vitro and in vivo X-ray imaging studies in albino rabbits. The result of all formulations for pre- and post-compression parameters were within the limits of USP. FTIR and DSC studies revealed no interaction between the drug and polymers used. The prepared floating tablets had good swelling and floating capabilities for more than 12 h with zero floating lag time. The release of valsartan from optimized formulation NF-2 showed sustained release up to 12 h; which was found to be non-Fickian release. Moreover, the X-ray imaging of optimized formulation (NF-2) revealed that tablet was constantly floating in the stomach region of the rabbit, thereby indicating improved gastric retention time for more than 12 h. Consequently, all the findings and outcomes have showed that developed valsartan matrix tablets could be effectively used for floating drug delivery system.

KEY WORDS

valsartan polypropylene foam powder carbopol floating tablets in vitro and in vivo evaluation 

Notes

Acknowledgements

The authors are thankful to Ranbaxy Labs (Hyderabad, India), Membrana GmbH, (Obernburg, Germany), and Shin Etsu Chemicals Co. (Paris, France) for providing the gift sample of valsartan, Accurel®MP1000, carbopol, lactose, and magnesium stearate, respectively.

Compliance with Ethical Standards

Ethical clearance for the research study that was obtained from the Institutional Animal Ethics Committee of East West College of Pharmacy, Bangalore, Karnataka, India constituted for the purpose.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Mohamed Rahamathulla
    • 1
    Email author
  • S. Saisivam
    • 2
  • H. V. Gangadharappa
    • 3
  1. 1.Department of PharmaceuticsKing Khalid UniversityAbhaSaudi Arabia
  2. 2.Department of PharmaceuticsN.R. Vekaria Institute of PharmacyJunegadIndia
  3. 3.Department of PharmaceuticsJSS College of Pharmacy, JSS Academy of Higher Education and ResearchMysoreIndia

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