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AAPS PharmSciTech

, Volume 19, Issue 8, pp 3742–3750 | Cite as

Mechanical Characterization and Dissolution of Chewing Gum Tablets (CGTs) Containing Co-compressed Health in Gum® and Curcumin/Cyclodextrin Inclusion Complex

  • Turki Al Hagbani
  • Christopher Altomare
  • Mohammad M. Kamal
  • Sami Nazzal
Research Article
  • 82 Downloads

Abstract

Curcumin chewing gums could be therapeutically beneficial if used by the head and neck cancer patients. High curcumin loading in chewing gums however is needed to achieve desired therapeutic effect. Preparing gums with high drug load is nonetheless challenging because of the negative impact of solids on their masticatory properties. The use of liquid flavors was found to partially solve this problem. The objectives of this study were to (1) determine the maximum amount of curcumin that can be loaded into co-compressed chewing gums made from Health in Gum® as the base and flavored with 1.5% peppermint oil, (2) determine if addition of sweeteners can improve the yield strength and compressibility of the gums when examined by a texture analyzer, (3) examine the effect of temperature over a storage period of one month on the physical stability of the chewing gums, and (4) study the impact of substituting curcumin with its inclusion complex with SBE-β-CD on drug release. It was found that when flavored, Health in Gum® could load up to 25% curcumin by weight without compromising its masticatory properties. When tested for drug release, SBE-β-CD was found to significantly increase the amount of curcumin dissolved within 30 min. Despite poor drug release from gums loaded with insoluble curcumin, the fragmentation of the gums during mastication by the Erweka tester is nonetheless expected to produce a suspension for absorption in the lower GIT. This study demonstrated how modulating gum composition and storage conditions can impact the mechanical properties of chewing gums with high solids content.

KEY WORDS

chewing gum curcumin cyclodextrin textural analysis tablet 

Notes

Acknowledgments

The government of Saudi Arabia and Hail University are acknowledged for providing fellowship support to T.A.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Aslani A, Rostami F. Medicated chewing gum, a novel drug delivery system. J Res Med Sci. 2015;20:403–11.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Kim SG, Veena MS, Basak SK, Han E, Tajima T, Gjertson DW, et al. Curcumin treatment suppresses IKKbeta kinase activity of salivary cells of patients with head and neck cancer: a pilot study. Clin Cancer Res. 2011;17:5953–61.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Nieuw Amerongen AV, Veerman EC. Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies. Support Care Cancer. 2003;11:226–31.PubMedGoogle Scholar
  4. 4.
    Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011;10:12.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, et al. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys. 2010;78:983–91.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    C.-A. Nathan, Microsized curcumin compositions, in, Google Patents, 2016.Google Scholar
  7. 7.
    C.A. Nathan, J.D. Boudreaux, Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders, in, Google Patents, 2017.Google Scholar
  8. 8.
    C.A. Nathan, J.D. Boudreaux, Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders, in, Google Patents, 2018.Google Scholar
  9. 9.
    Zhang F, Koh GY, Jeansonne DP, Hollingsworth J, Russo PS, Vicente G, et al. A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity. J Pharm Sci. 2011;100:2778–89.CrossRefPubMedGoogle Scholar
  10. 10.
    T. Al Hagbani, S. Nazzal, Development of postcompressional textural tests to evaluate the mechanical properties of medicated chewing gum tablets with high drug loadings. J Texture Stud, (2017).Google Scholar
  11. 11.
    Hagbani TA, Nazzal S. Curcumin complexation with cyclodextrins by the autoclave process: method development and characterization of complex formation. Int J Pharm. 2017;520:173–80.CrossRefPubMedGoogle Scholar
  12. 12.
    Stojanov M, Larsen KL. Cetirizine release from cyclodextrin formulated compressed chewing gum. Drug Dev Ind Pharm. 2012;38:1061–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Heath DD, Pruitt MA, Brenner DE, Rock CL. Curcumin in plasma and urine: quantitation by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;783:287–95.CrossRefPubMedGoogle Scholar
  14. 14.
    Newton JM, Rowley G, Fell JT, Peacock DG, Ridgway K. Computer analysis of the relation between tablet strength and compaction pressure. J Pharm Pharmacol. 1971;23:195S–201S.CrossRefPubMedGoogle Scholar
  15. 15.
    M.R. Marques, R. Loebenberg, M. Almukainzi, Simulated biological fluids with possible application in dissolution testing.Google Scholar
  16. 16.
    Peyron M-A, Mioche L, Culioli J. Bite force and sample deformation during hardness assessment of viscoelastic models of foods. J Texture Stud. 1994;25:59–76.CrossRefGoogle Scholar
  17. 17.
    D. Mazurek, J.T. DeWolf, F.P. Beer, E.R. Johnston, Statics and Mechanics of Materials, McGraw-Hill Education, 2016.Google Scholar
  18. 18.
    D. Hull, D.J. Bacon, Introduction to Dislocations, Elsevier Science, 2011.Google Scholar
  19. 19.
    Bourne MC. Food Texture and Viscosity: Concept and Measurement. New York: Academic Press, Inc.; 1982.Google Scholar
  20. 20.
    Roberts M, Ehtezazi T, Compernolle A, Amin K. The effect of spray drying on the compaction properties of hypromellose acetate succinate. Drug Dev Ind Pharm. 2011;37:268–73.CrossRefPubMedGoogle Scholar
  21. 21.
    Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–18.CrossRefPubMedGoogle Scholar
  22. 22.
    Yadav VR, Suresh S, Devi K, Yadav S. Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model. AAPS PharmSciTech. 2009;10:752–62.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Turki Al Hagbani
    • 1
    • 2
  • Christopher Altomare
    • 3
  • Mohammad M. Kamal
    • 1
  • Sami Nazzal
    • 1
    • 4
  1. 1.College of PharmacyUniversity of Louisiana at MonroeMonroeUSA
  2. 2.College of PharmacyHail UniversityHailSaudi Arabia
  3. 3.DrugScan Pharmaceutical ServicesHorshamUSA
  4. 4.Department of Pharmaceutical Sciences, School of PharmacyTexas Tech University Health Sciences CenterDallasUSA

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