AAPS PharmSciTech

, Volume 19, Issue 7, pp 3000–3008 | Cite as

Preparation and Characterization of Tetrahydrocurcumin-Loaded Cellulose Acetate Phthalate/Polyethylene Glycol Electrospun Nanofibers

  • Ravikumar Rramaswamy
  • Ganesh Mani
  • Senthil Venkatachalam
  • Ramesh Venkata Yasam
  • J. C. Bose Rajendran
  • Jang Hyun TaeEmail author
Research Article


A simple composite electrospun nanofiber of cellulose acetate phthalate (CAP)-polyethylene glycol (PEG) loaded with tetrahydrocurcumin (THC) was developed in this study, and the in vitro diffusion of THC was evaluated. The nanofibers were characterized by scanning electron microscopy, powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). The formulated nanofiber (NF) with THC has smooth morphology with diameter of around 300–500 nm. The complete entrapment and dispersion of THC was observed from the results of PXRD and DSC due to the loss of THC crystalline property. Further, FT-IR demonstrated that the vibration bands for the polymers used were dominant over the THC, and the vibrational bands of THC were not observed from the final formulation. The drug entrapment by the final CAP + PEG NF was found to be 95.5% with the high swelling index. From the in vitro release study, it was found that the formulated THC-loaded CAP + PEG NF has followed anomalous mechanism, demonstrating both diffusion and swelling controlled modes. The drug release extended up to 12 h with a final cumulative release of 94.24%.


polymers tetrahydrocurcumin electrospinning nanofibers in vitro evaluations 



This work was supported by the Hanseo University Intramural Research Grant, South Korea (2017).

Compliance with Ethical Standards

Conflicts of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12249_2018_1122_MOESM1_ESM.doc (221 kb)
ESM 1 (DOC 221 kb)


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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Ravikumar Rramaswamy
    • 1
    • 2
  • Ganesh Mani
    • 2
  • Senthil Venkatachalam
    • 3
  • Ramesh Venkata Yasam
    • 3
  • J. C. Bose Rajendran
    • 4
  • Jang Hyun Tae
    • 2
    Email author
  1. 1.Department of Advanced Materials Science and EngineeringHanseo UniversitySeosan-SiSouth Korea
  2. 2.Department of Chemical EngineeringHanseo UniversitySeosan-SiSouth Korea
  3. 3.Department of PharmaceuticsJSS College of PharmacyThe NilgirisIndia
  4. 4.Department of RadiologyStanford University School of MedicineStanfordUSA

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