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AAPS PharmSciTech

, Volume 19, Issue 6, pp 2719–2739 | Cite as

Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin

  • Muhammad Usman Akbar
  • Khalid Mahmood Zia
  • Ahsan Nazir
  • Jamshed Iqbal
  • Syeda Abida Ejaz
  • Muhammad Sajid Hamid Akash
Research Article

Abstract

Curcumin is a naturally occurring constituent of turmeric that is a good substitute for synthetic medicines for the treatment of different diseases, due to its comparatively safer profile. However, there are certain shortcomings that limit its use as an ideal therapeutic agent. In order to overcome these drawbacks, we prepared novel curcumin-loaded mixed polymeric micelles using different biocompatible polymers by the thin-film hydration method. We investigated the critical micelle concentration and temperature, drug loading and encapsulation efficiency, and minimum inhibitory concentration by spectrophotometry. Surface morphology, stability, particle size, drug-polymer interaction, and physical state of the prepared formulations were investigated using scanning electron microscopy, zeta potential, particle size analyzer, Fourier-transform infrared spectroscopy, and X-ray diffraction, respectively. The drug loading and entrapment efficiency were significantly increased (P < 0.01) when curcumin was encapsulated with pluronic-based mixed polymeric micelles as compared to that of pluronic-based micelles alone. In vitro studies exhibited that pluronic-based mixed polymeric micelles significantly increased anticancer (P < 0.01), antimicrobial (P < 0.001), antioxidant (P < 0.001), and α-amylase inhibitory (P < 0.001) activities when compared to pure curcumin and/or pluronic-based micelles alone. These findings suggest that the formation of mixed polymeric micelles increases the stability and solubility of curcumin.

KEY WORDS

mixed polymeric micelles micelle characterization drug delivery system 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  1. 1.Department of Applied ChemistryGovernment College UniversityFaisalabadPakistan
  2. 2.Department of Pharmaceutical ChemistryGovernment College UniversityFaisalabadPakistan
  3. 3.Department of Textile ChemistryNational Textile UniversityFaisalabadPakistan
  4. 4.Center for Advanced Drug Research, Department of PharmacyCOMSATS Institute of Information TechnologyAbbottabadPakistan

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