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AAPS PharmSciTech

, Volume 19, Issue 5, pp 2058–2067 | Cite as

Development of Microemulsions and Microemulgels for Enhancing Transdermal Delivery of Kaempferia parviflora Extract

  • Worranan Rangsimawong
  • Paisit Wattanasri
  • Prasopchai Tonglairoum
  • Prasert Akkaramongkolporn
  • Theerasak Rojanarata
  • Tanasait Ngawhirunpat
  • Praneet Opanasopit
Research Article
  • 64 Downloads

Abstract

The purpose of this research was to develop microemulsions (ME) and microemulgels (MG) for enhancing transdermal delivery of Kaempferia parviflora (KP) extract. The methoxyflavones were used as markers. Various formulations of ME and MG containing 10% w/v KP extract were prepared, and the in vitro skin permeation and deposition were investigated. The potential ME system containing oleic acid (5% w/v), Tween 20 (20% w/v), PG (40% w/v), and water (35% w/v) was successfully formulated. ME with 10% w/v limonene (ME-L10%) showed higher methoxyflavones flux than ME-L5%, ME-L1%, ME without limonene, and KP extract in water, respectively. ME-L10% was selected for adding a gelling agent to form microemulgels (MG-L10%). However, the high viscosity of the gel formulation might control the diffusion of the compound from gel layer into the skin. Therefore, the liquid formulation provided potential ME droplets to deliver KP extract through the skin. Limonene also plays an effective role on the skin permeation, in which the histological image of the skin treated with ME-L10% exhibited larger space of each flattened keratinocyte layer in the stratum corneum compared to the skin treated with KP extract in water. Moreover, ME-L10% showed good stability. Therefore, ME-L10% was a potential formulation for improving transdermal delivery of KP extract.

KEY WORDS

Kaempferia parviflora microemulsions microemulgels limonene skin permeation 

Notes

Acknowledgements

The authors would like to acknowledge the Faculty of Pharmacy, Silpakorn University, the Thailand Research Funds (IRN58W0004), and the National Natural Science Foundation of China (NSFC 81561148012) for the financial supports and Bangkok Lab & Cosmetic Co., Ltd., for Kaempferia parviflora (KP) extract and standard methoxyflavones.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Supplementary material

12249_2018_1003_MOESM1_ESM.docx (62 kb)
ESM 1 (DOCX 62 kb)

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Worranan Rangsimawong
    • 1
  • Paisit Wattanasri
    • 1
    • 2
  • Prasopchai Tonglairoum
    • 1
  • Prasert Akkaramongkolporn
    • 1
  • Theerasak Rojanarata
    • 1
  • Tanasait Ngawhirunpat
    • 1
  • Praneet Opanasopit
    • 1
  1. 1.Faculty of PharmacySilpakorn UniversityNakhon PathomThailand
  2. 2.Bangkok Lab & Cosmetic Co., Ltd.RatchaburiThailand

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