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The AAPS Journal

, 21:17 | Cite as

What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing

  • Thomas M. PolasekEmail author
  • Amin Rostami-Hodjegan
  • Dong-Seok Yim
  • Masoud Jamei
  • Howard Lee
  • Holly Kimko
  • Jae Kyoung Kim
  • Phuong Thi Thu Nguyen
  • Adam S. Darwich
  • Jae-Gook Shin
Meeting Report
  • 77 Downloads

Abstract

Model-informed precision dosing (MIPD) is modeling and simulation in healthcare to predict the drug dose for a given patient based on their individual characteristics that is most likely to improve efficacy and/or lower toxicity in comparison to traditional dosing. This paper describes the background and status of MIPD and the activities at the 1st Asian Symposium of Precision Dosing. The theme of the meeting was the question, “What does it take to make MIPD common practice?” Formal presentations highlighted the distinction between genetic and non-genetic sources of variability in drug exposure and response, the use of modeling and simulation as decision support tools, and the facilitators to MIPD implementation. A panel discussion addressed the types of models used for MIPD, how the pharmaceutical industry views MIPD, ways to upscale MIPD beyond academic hospital centers, and the essential role of healthcare professional education as a way to progress. The meeting concluded with an ongoing commitment to use MIPD to improve patient care.

Notes

Acknowledgements

Finance from Inje University and Certara was provided to support the symposium. The authors are grateful to Ms. (Emma) Si Yeon Nam from the Pharmacogenomics Research Center at Inje University for her efforts in organizing the symposium, and to all the attendees who made the day very informative and enjoyable.

Compliance with Ethical Standards

Conflict of Interest

Thomas M. Polasek, Amin Rostami-Hodjegan, and Masoud Jamei are employees of Certara. Certara makes modeling and simulation software, including one type of PBPK platform (Simcyp®), which is used by the pharmaceutical industry for drug development. All other authors declare that they have no conflicts of interest.

Disclaimer

This article reflects the views of the authors and should not be construed to represent their organizations’ views or policies.

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Copyright information

© American Association of Pharmaceutical Scientists 2019

Authors and Affiliations

  • Thomas M. Polasek
    • 1
    • 2
    Email author return OK on get
  • Amin Rostami-Hodjegan
    • 1
    • 3
  • Dong-Seok Yim
    • 4
  • Masoud Jamei
    • 1
  • Howard Lee
    • 5
    • 6
  • Holly Kimko
    • 7
  • Jae Kyoung Kim
    • 8
  • Phuong Thi Thu Nguyen
    • 9
    • 10
  • Adam S. Darwich
    • 3
  • Jae-Gook Shin
    • 9
  1. 1.CertaraPrincetonUSA
  2. 2.Centre for Medicines Use and SafetyMonash UniversityMelbourneAustralia
  3. 3.Centre for Applied Pharmacokinetic ResearchUniversity of ManchesterManchesterUK
  4. 4.Department of Pharmacology, College of MedicineThe Catholic University of KoreaSeoulSouth Korea
  5. 5.Department of Clinical Pharmacology and TherapeuticsSeoul National University College of Medicine and HospitalSeoulSouth Korea
  6. 6.Department of Transdisciplinary Studies, Graduate School of Convergence Science and TechnologySeoul National UniversitySeoulSouth Korea
  7. 7.Janssen Research and DevelopmentLower Gwynedd TownshipUSA
  8. 8.Korea Advanced Institute of Advanced TechnologyDaejeonSouth Korea
  9. 9.Department of Pharmacology and Clinical Pharmacology, Pharmacogenomics Research CenterInje University College of MedicineBusanRepublic of Korea
  10. 10.Faculty of PharmacyHaiphong University of Medicine and PharmacyHaiphongVietnam

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