Abstract
This study tested the general hypothesis that high- and low-hostile respondents would show different patterns of change in monocyte cytokine and adhesion protein (MCAP) expression in response to pharmacologically induced alterations in sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) balance. On 3 separate days, 4 high- and 4 low-hostile respondents received isoproterenol infusions after saline, atropine (PNS blockade), or neostigmine (PNS stimulation) pretrcatment. Dual color flow cytometry with fluorescently labeled monoclonal antibodies to CD 14 (monocyte marker), interleukin-I, leukocyte function activator (LFA-1), Class II major histocompatibility complex (MHC-II), and tumor necrosis factor was used to quantify cytokine and adhesion protein expression on monocytes in blood samples drawn before and after the combination drug infusions on the 3 test days in each respondent. Following PNS stimulation and isoproterenol infusion there was a decrease (compared to saline pretreatment) in MHC II expression in high hostiles that was significantly (p > .02) different from an increase in low hostiles. A similar trend (p = .08) was seen for LFA-1 expression, with high hostiles showing an increase and low hostiles a decrease. These findings support the broad hypothesis that high-and tow-hostile respondents will show different MCAP responses 10 pharmacologically induced alterations in SNS-PNS balance. Such differences could contribute to accelerated atherogenesis among high-hostile individuals.
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This research was supported by giants from the National Heart, Lung and Blood Institute (P01-HL36587, R01-HL44998): the National Institute of Mental Health (K05-MH70482); the National Institute on Aging (5P60-AGII268. PO-AGI 2058); National Center for Research Resources. General Clinical Research Centers Program (M0l-RR-30), National Institutes of Health; and the Fetzer Institute.
This article is dedicated to the memory of Dolph O. Adams, who died on August 9, 1996.
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Williams, R.B., Sasaki, M., Lewis, J.G. et al. Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans. Int. J. Behav. Med. 4, 264–272 (1997). https://doi.org/10.1207/s15327558ijbm0403_5
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DOI: https://doi.org/10.1207/s15327558ijbm0403_5