International Journal of Behavioral Medicine

, Volume 3, Issue 4, pp 321–336 | Cite as

Is there an association among low untreated serum lipid levels, anger, and hazardous driving?

  • Karina W. Davidson
  • S. Sethu K. Reddy
  • Patrick McGrath
  • David Zitner


Anger and hazardous driving were explored in two studies for their possible explanatory role in the low cholesterol-violent mortality association. In Study 1, we obtained fasting blood samples and indices of anger and driving habits from 102 healthy young adults. Among men (but not women), lower low-density lipoprotein (LDL) cholesterol levels were associated with significantly higher anger (r = -.41, p < .01) and unsafe driving habits (r = -.30, p < .05), and although total cholesterol levels were correlated in the predicted direction, these were not significant. In Study 2,78 healthy young men completed the same measures, and this time, both lower total and LDL-cholesterol were significantly related to increased anger and dangerous driving. Implications of these Findings are discussed as are possible avenues for future research. Further scrutiny of the components of serum cholesterol and their relation to psychological factors may aid us in better understanding the reasons why men are at increased risk for hazardous behavior and violent death.

Key words

low cholesterol anger sex differences hazardous behavior 


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  1. Arntzenius, A. C., Kromhout, D., Barth, J. D., Reiber, H. H. C., Bruschke, A. V. G., Buis, B., vanGent, C. M., Kempen-Voogd, N., Strikwerda, S., & van der Velde, E. A. (1985), Diet, lipoproteins, and the progress of coronary atherosclerosis: The Leiden Intervention Trial. New England Journal of Medicine, 312, 805–811.PubMedGoogle Scholar
  2. Blankenhorn, D. H., Nessim, S. A., Johnson, R. L., Sonmarco, M. E., Azen, S. P., & Cashin-Hemphill, L. (1987). Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. Journal of the American Medical Association, 257, 3233–3240.PubMedCrossRefGoogle Scholar
  3. Browner, W. S., Westenhouse, J., & Tice, J. A. (1991). What if Americans ate less fat? A quantitative estimate of the effect on mortality. Journal of the American Medical Association, 265, 3285–3291.PubMedCrossRefGoogle Scholar
  4. Buchwald, H., Varco, R. I., Matts, J. P., Long, J. M., Fitch, L. L., Campbell, G. S., Pearce, M. B., Yellin, A. E., Edmiston, W. A., Smink, R. D., Sawin, H. S., Campos, C. T., Hanson, B. J., Tuna, N., Kamegis, J. N., Sanmarco, M. E., Amplatz, K., Castaneda-Zuniga, W. R., Hunter, D. W., Bissett, J. K., Weber, F. J., Stevenson, J. W., Leon, A. S., Chalmers, T. C., & POSCH Group. (1990). Effects of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. New England Journal of Medicine, 323, 946–955.PubMedGoogle Scholar
  5. Canadian Consensus Conference on Cholesterol. (1988). Final Report. Canadian Medical Association Journal, 139(Suppl. 11), 1–8.Google Scholar
  6. Chen, Z., Peto, R., Collins, R., MacMahon, S., Lu, J., & Li, W. (1991). Serum cholesterol and coronary heart disease in a population with low cholesterol concentrations. British Medical Journal, 303, 276–282.PubMedGoogle Scholar
  7. Connelly, P. W., MacLean, D. R., Horlick, L., O’Connor, B., Petrasovits, A., Little, A., & The Canadian Heart Health Survey Research Group. (1992). Plasma lipids and lipoproteins and prevalence of risk for coronary heart disease in Canadian adults. Canadian Medical Association Journal, 146(Suppl. 1), 9–19.Google Scholar
  8. Conroy, R. M. (1993). Low cholesterol and violent death: The evidence, the gaps, the theory and the practical implications. Irish Journal of Psychological Medicine, 10, 67–70.Google Scholar
  9. Cummings, P., & Psaty, B. M. (1994). The association between cholesterol and death from injury. Annuls of Internal Medicine, 120, 848–855.Google Scholar
  10. Dayton, S., Pearce, M. L., Hashimoto, S., Dixon, W. J., & Tomiyasu, U. (1969). A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation, 39–40(Suppl.), 1–63.Google Scholar
  11. Draeger, B., Wahlefeld, A. W., & Ziegcnhorn, J. (1955). Cholesterol: HDL-cholesterol. In J. Bergmeyer & M. Grassl (Eds.), Methods of enzymatic analysis: Vol. VIII: Metabolites 3: Lipids, amino acids and related compounds (3rd ed., pp. 148–154). Deerfield Beach, FL: Verlag Chemie.Google Scholar
  12. Engelberg, H. (1992). Low serum cholesterol and suicide. Lancet, 339, 727–729.PubMedCrossRefGoogle Scholar
  13. Farchi, G., Menotti, A., & Conti, S. (1987). Coronary risk factors and survival probability from coronary and other causes of death. American Journal of Epidemiology, 126, 400–408.PubMedGoogle Scholar
  14. Fowkes, F. G. R., Leng, G. C., Donnan, P. T., Dearym, I. J., Riemersma, R. A., & Housley, E. (1992). Serum cholesterol, triglycerides, and aggression in the general population. Lancet, 340, 995–998.PubMedCrossRefGoogle Scholar
  15. Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttenen, J. K., Kaiteniemi, P., Koshkinen, P., Manninen, V., Maenpaa, H., Malkonen, M., Mantarri, M., Norola, S., Pastemack, A., Pikkarainen, J., Romo, M., Sjoblom, T., & Nikkila, E. A. (1987). Helsinki heart study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. New England Journal of Medicine, 317, 1237–1244.PubMedGoogle Scholar
  16. Friedwald, W. T., Levy, R. I., & Fredrickson, D. S. (1972). Estimation of the concentrations of low-density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clinical Chemistry, 18, 499–502.Google Scholar
  17. Griffin, K. W., & Weidner, G. (1994). Cholesterol-lowering and psychological well-being. Compressive Therapy, 20, 518–522.Google Scholar
  18. Guicheney, P., Devynck, M. A., Cloix, J. F., Pemollet, M. G., Grichois, M. L., & Meyer, P. (1988). Platelet 5-HT content and uptake in essential hypertension. Role of endogenous digitalis-like factors and plasma cholesterol. Journal of Hypertension, 6, 115–126.CrossRefGoogle Scholar
  19. Harris, T., Feldman, J. J., Kleinman, J. C., Ettinger, W. H., Jr., Makuc, D. M., & Schatzkin, A. G. (1992). The low cholesterol-mortality association in a national cohort. Journal of Clinical Epidemiology, 45, 595–601.PubMedCrossRefGoogle Scholar
  20. Hettler, B. (1978). A lifestyle improvement program that pays for itself. In Proceedings of the fourteenth meeting of the Society of Prospective Medicine (pp. 13–17). Bethesda, MD.Google Scholar
  21. Hillbrand, M., Spitz, R. T., & Foster, H. G. (1995). Serum cholesterol and aggression in hospitalized male forensic patients. Journal of Behavioral Medicine, 18, 33–43.PubMedCrossRefGoogle Scholar
  22. Hulley, S. B., Walsh, J. B. M., & Newman, T. B. (1992). Health policy on blood cholesterol: Time to change directions. Circulation, 86, 1026–1029.PubMedGoogle Scholar
  23. Jacobs, D., Blackburn, H., Higgens, M., Reed, D., Iso, H., McMillan, G., Nealon, J., Nelson, J., Potter, J., Rifkind, B., Rossouw, J., Shekelle, R., & Yusuf, S. (1992). Report of the conference on low blood cholesterol: Mortality associations. Circulation, 86, 1046–1060.PubMedGoogle Scholar
  24. Kaplan, J. R., Manuck, S. B., & Shivcly, C. (1991). The effects of fat and cholesterol on social behavior in monkeys. Psychosomatic Medicine, 53, 634–642.PubMedGoogle Scholar
  25. LaRosa, J. C., Hunninghake, D., Bush, D., Criqui, M. H., Getz, G. S., Gotto, A. M., Jr., Grundy, S. M., Rakita, L., Robertson, R. M., Weisfeldt, M. L., Cleeman, J. I., & Writing Group (1990). The cholesterol facts: A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. Circulation, 81, 1721–1733.PubMedGoogle Scholar
  26. Lindberg, G., Rastam, L., Gullberg, B., & Gunnar, G. A. (1992). Low serum cholesterol concentration and short-term mortality from injuries in men and women. British Medical Journal, 305, 277–279.PubMedGoogle Scholar
  27. Lipid Research Clinics Program. (1984). The lipid research clinics coronary primary prevention trial’s results—I. Reduction in the incidence of coronary heart disease. Journal of the American Medical Association, 251, 351–364.CrossRefGoogle Scholar
  28. Lundberg, V., Hedman, M., Metin, B., & Frankenhaeuser, M. (1989). Type A behavior in healthy males and females as related to physiological reactivity and blood lipids. Psychosomatic Medicine, 51, 113–122.PubMedGoogle Scholar
  29. Mason, R. P., Herbette, L. G., & Silverman, D. I. (1991). Can altering serum cholesterol affect neurologic function? Journal of Molecular Cellular Cardiology, 23, 1339–1342.CrossRefGoogle Scholar
  30. Muldoon, M. R., & Manuck, S. B. (1992). Health through cholesterol reduction: Are there unforeseen risks? Annals of Behavioral Medicine, 14, 101–108.Google Scholar
  31. Muldoon, M. F., Manuck, S. B., & Matthews, K. A. (1990). Lowering cholesterol concentrations and mortality: A quantitative review of primary prevention trials. British Medical Journal, 301, 309–314.PubMedCrossRefGoogle Scholar
  32. Nagele, U., Wahlefeld, A. W., & Ziegenhom, J. (1985), Triglycerides: Colorimetric methods. In J. Bergmeyer & M. Grassl (Eds.), Methods of enzymatic analysis: Vol. VIII: Metabolites 3: Lipids, amino acids and related compounds (3rd ed., pp. 12–18). Deerfield Beach, FL: Verlag Chemie.Google Scholar
  33. National Cholesterol Education Program. (1988). Report of expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Archives of Internal Medicine, 148, 36–69.CrossRefGoogle Scholar
  34. National Wellness Institute. (1992). The Lifestyle Assessment Questionnaire. Stevens Point, WI: Author.Google Scholar
  35. Nova Scotia Department of Health and Department of National Health and Welfare. (1987). Report of the Nova Scotia Heart Health Survey. Ottawa: Author.Google Scholar
  36. Oliver, M. F. (1988). Reducing cholesterol does not reduce mortality. Journal of the American College of Cardiology, 12, 814–817.PubMedCrossRefGoogle Scholar
  37. Palombi, B. J. (1992). Psychometric properties of wellness instruments. Journal of Counselling and Development, 71, 221–225.Google Scholar
  38. Pekkanen, J., Nissinen, A., Punsar, S., & Karvonen, M. (1989), Serum cholesterol and risk of accidental or violent death in a 25-year follow-up. Archives of Internal Medicine, 149, 1589–1591.PubMedCrossRefGoogle Scholar
  39. Preston, M. R., Herbette, L., & Silverman, D. (1991). Can altering serum cholesterol affect neurologic function? Journal of Molecular Cell Cardiology, 23, 1339–1342.CrossRefGoogle Scholar
  40. Scandinavian Simvastatin Survival Study Group. (1994). Randomized trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival study (4S). The Lancet, 344, 1383–1389.Google Scholar
  41. Siedel, J., Rollinger, W., Roschlau, P., & Ziegenhom, J. (1985). Cholesterol: Total cholesterol, end-point and kinetic method, In J. Bergmeyer & M. Grassl (Eds.), Methods of enzymatic analysis: Vol, VIII: Metabolites 3: Lipids, amino acids and related compounds (3rd ed., pp. 139–148). Deerfield Beach, FL: Verlag Chemie.Google Scholar
  42. Siegel, J. M. (1985). The measurement of anger as a multidimensional construct. In M. A. Chesney & R. H. Rosenman (Eds.), Anger and hostility in cardiovascular and behavioral disorders (pp. 59–83). Washington. DC: Hemisphere Publishing Corporation.Google Scholar
  43. Siegel, J. M. (1986). The Multidimensional Anger Inventory. Journal of Personality and Social Psychology, 51, 191–200.PubMedCrossRefGoogle Scholar
  44. Smith, G. D., Shipley, M. J., Marmot, M. G., & Rose, G. (1992). Plasma cholesterol concentration and mortality: The Whitehall study. Journal of the American Medical Association, 267, 71–76.CrossRefGoogle Scholar
  45. Virkkunen, M. (1979). Serum cholesterol in antisocial personality. Neuropsychobiology, 5, 27–30.PubMedCrossRefGoogle Scholar
  46. Virkkunen, M. (1983). Serum cholesterol levels in homicidal offenders: A low cholesterol level is connected with a habitually violent tendency under the influence of alcohol. Neuropsychobiology, 10, 65–69.PubMedCrossRefGoogle Scholar
  47. Virkkunen, M., Horrobin, D. F., Jenkins, D. K., & Manku, M. S. (1987). Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. Biological Psychiatry, 22, 1087–1096.PubMedCrossRefGoogle Scholar
  48. Virkkunen, M., & Penttinen, H.(1984). Serum cholesterol in aggressive conduct disorder: A preliminary study. Biological Psychiatry, 19, 435–439.PubMedGoogle Scholar
  49. Weidner, G., Connor, S. J., Hollis, J. R. & Connor, W. E. (1992). Improvements in hostility and depression in relation to dietary change and cholesterol lowering: The Family Heart study. Annals of Internal Medicine, 117, 820–823.PubMedGoogle Scholar
  50. Weidner, G., Sexton, G., McLellarn, R., Connor, S. L., & Matarazzo, J. D. (1987). The role of Type A behavior and hostility in an elevation of plasma lipids in adult women and men. Psychosomatic Medicine, 49, 136–145.PubMedGoogle Scholar
  51. Wysowski, D. K., & Gross, T. P. (1990). Deaths due to accidents and violence in two recent trials of cholesterol-lowering drugs. Archives of Internal Medicine, 150, 2169–2172.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Behavioral Medicine 1996

Authors and Affiliations

  • Karina W. Davidson
    • 1
  • S. Sethu K. Reddy
    • 2
  • Patrick McGrath
    • 1
  • David Zitner
    • 3
  1. 1.Department of PsychologyDalhousie University, University of AlabamaHalifax, TuscaloosaCanada
  2. 2.Departments of Medicine and BiochemistryDalhousie UniversityHalifaxCanada
  3. 3.Department of Family MedicineDalhousie UniversityHalifaxCanada

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