A case of atypical type A thymoma variant
- 621 Downloads
An atypical type A thymoma variant was newly added to the WHO classification of type A thymoma family in 2015.
A 72-year-old female was present a large round mass in the anterior mediastinum. The radiological examination led to a preoperative diagnosis of non-invasive thymoma. Tumor resection was undertaken via median sternotomy. Complete removal of the mediastinal tumor was achieved. Pathological examination revealed that the tumor cells were spindle- and oval-shaped with atypia. Immunohistochemical work-up revealed that the tumor was type A thymoma. On the basis of these findings, the tumor was finally diagnosed to be an atypical type A thymoma variant.
Preoperative diagnosis as atypical type A thymoma variant based on radiological examination is difficult. In case of atypical type A thymoma variant, a careful postoperative systemic follow-up should be done.
KeywordsThymoma Atypia Median sternotomy
Terminal deoxynucleotidyl transferase
In general, type A thymoma is recognized as a benign tumor with excellent prognosis . However, several authors have reported type A thymoma showing atypical features with postoperative tumor relapse [2, 3, 4]. On the basis of these reports, atypical type A thymoma variant was added to the type A thymoma family as a small subset of aggressive tumors [5, 6]. Here, we present the case of an atypical type A thymoma variant.
Our preoperative diagnosis was a non-invasive thymoma, and she underwent tumor resection via median sternotomy. The operative findings revealed that the tumor did not invade the surrounding organs, and we could easily dissect the tumor.
Her postoperative course was uneventful, and she was discharged on foot 12 days after surgery. She is doing well without recurrence until last follow-up at 15 months after operation. We continue to conduct careful postoperative follow-up.
An atypical type A thymoma variant was added to the WHO classification of type A thymoma family in 2015  based on several reports about type A thymoma with oncological aggressive behavior and tumor relapses [2, 3, 4]. Pathological findings present the most specific feature of atypical type A thymoma. These are as follows: (1) mild to moderate nuclear atypia, (2) increase in mitotic activity, and (3) a scattered foci of necrosis. These findings are usually present in type B3 thymoma rather than the conventional type A thymoma. Vladislav and coworkers described that the frequency of type A thymoma with these aggressive behavior was 3.8 % (23/600 cases) . In this case, the patient presented with mild atypia, hypercellularity, and high mitotic activity, which was 8–10 mitoses per 2 mm2. This distribution was denser than conventional type A thymoma where the count is usually <4 mitoses per 2 mm2.
On the other hand, specific finding of radiological examination was still unknown. CECT could show the possibility of tumor invasiveness to surrounding organ, but it would not reflect of morphological behavior. Recently, PET-CT has been known as a useful examination about thymic epithelial tumors, especially thymoma [7, 8]. Park and coworkers showed that significant relationship was observed between SUVmax and WHO classification, mean SUVmax in low-risk thymoma (A, AB, and B1) was 3.43, and high-risk thymoma (B2 and B3) was 4.42 . However, in this case, SUVmax was 3.5; it might not be able to predict the morphological behavior. As these results, neither CECT nor PET-CT contributes preoperative definitive diagnosis of atypical type A thymoma variant.
Vladislav and coworkers showed that tumor relapse, including distant metastases, occurred in 43 % (10/23 patients) cases of type A thymoma showing atypical features . This relapse rate is much higher than that of conventional type A thymoma.
The mean duration of time to metastases was 39.7 months (7–107 months). Of these 10 patients, lung metastasis was found in 5, and liver metastasis in 4. Regarding surgical margin and postoperative tumor metastasis, contrary to logic, development of metastatic disease was observed more frequently in the patients with negative surgical margin than positive or close (<1 mm) surgical margin. And they also described that only the presence of necrosis is a predictive factor of tumor relapse, including distant metastases, and no other factors such as the stage of diagnosis, tumor size, nuclear shape, nuclear variability, and mitotic activity correlate with tumor relapse. These suggested that postoperative follow-up about not only intrathoracic cavity but also extrathoracic cavity is essential.
Ki-67 is a well-known histological marker of proliferation used as an index of biological aggressiveness in various solid tumors. It has already been reported that Ki-67 labeling index (LI) correlates with the tumor aggressiveness in thymic epithelial neoplasm . In that report, Ki-67 LI in type A thymoma was 0.3–11.0 % (median 3.0) and in thymic carcinoma was 12.2–43.3 % (median 23.2 %) . Ki-67 LI in the present case was 23.3 %, which suggests that the aggressiveness of this tumor is similar to that of thymic carcinoma. The correlation between Ki-67 LI and tumor relapse in thymoma is not confirmed, but careful postoperative follow-up may be essential in atypical type A thymoma variant.
Here, we presented the case of an atypical type A thymoma variant. It is notable that radiological examination did not contribute to the definitive diagnosis of the atypical type A thymoma variant. When we encounter the case of atypical type A thymoma variant, careful postoperative systemic follow-up should be conducted.
The authors would like to thank Enago (http://www.enago.jp) for the English language review.
MH, SS, TT (Takuwa), and SH conceived and designed this study. SS, YT, and TT (Tsujimura) evaluated the pathological findings. MH and SS drafted the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for publication of this manuscript and any accompanying images.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.