Table 3 Heritability estimation at top 47 CpG sites of MGMT with common environmental component at two time points

From: Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

CpG site Year 1997 Year 2007
a2 c2 e2 a2 c2 e2
cg03751055c 0.0000 (0.0000–0.0000) 0.9792 (0.9629–0.9955) 0.0208 (0.0045–0.0371) 0.0000 (0.0000–0.0000) 0.9841 (0.9716–0.9966) 0.0159 (0.0034–0.0284)
cg25063211c 0.0000 (0.0000–0.0000) 0.8925 (0.8297–0.9554) 0.1075 (0.0446–0.1703) 0.0000 (0.0000–0.0000) 0.6785 (0.4072–0.9498) 0.3215 (0.0502–0.5928)
cg07933035c 0.0000 (0.0000–0.0000) 0.8541 (0.7232–0.9851) 0.1459 (0.0149–0.2768) 0.0000 (0.0000–0.0000) 0.8015 (0.6090–0.9941) 0.1985 (0.0059–0.3910)
cg12434587c 0.0000 (0.0000–0.0000) 0.8136 (0.6495–0.9777) 0.1864 (0.0223–0.3505) 0.0000 (0.0000–0.0000) 0.8186 (0.6494–0.9878) 0.1814 (0.0122–0.3506)
cg26102564c 0.0000 (0.0000–0.0000) 0.7358 (0.5942–0.8774) 0.2642 (0.1226–0.4058) 0.0000 (0.0000–0.0000) 0.8214 (0.7199–0.9229) 0.1786 (0.0771–0.2801)
cg18811130c 0.0000 (0.0000–0.0000) 0.6892 (0.5240–0.8544) 0.3108 (0.1456–0.4760) 0.0000 (0.0000–0.0000) 0.7466 (0.6094–0.8838) 0.2534 (0.1162–0.3906)
cg12981137c 0.0000 (0.0000–0.0000) 0.6138 (0.2981–0.9295) 0.3862 (0.0705–0.7019) 0.0000 (0.0000–0.0000) 0.7168 (0.4396–0.9940) 0.2832 (0.0060–0.5604)
cg02941816c 0.0000 (0.0000–0.0000) 0.5689 (0.1537–0.9841) 0.4311 (0.0159–0.8463) 0.0000 (0.0000–0.0000) 0.7174 (0.4562–0.9786) 0.2826 (0.0214–0.5438)
cg13474692c 0.0000 (0.0000–0.0000) 0.5595 (0.1543–0.9646) 0.4405 (0.0354–0.8457) 0.0000 (0.0000–0.0000) 0.6074 (0.1231–1.0917) 0.3926 (− 0.0917–0.8769)
cg02750154c 0.0000 (0.0000–0.0000) 0.5114 (0.2660–0.7567) 0.4886 (0.2433–0.7340) 0.0000 (0.0000–0.0000) 0.7505 (0.6022–0.8988) 0.2495 (0.1012–0.3978)
cg18581292c 0.0000 (0.0000–0.0000) 0.3584 (0.0683–0.6484) 0.6416 (0.3516–0.9317) 0.0000 (0.0000–0.0000) 0.4864 (0.2308–0.7420) 0.5136 (0.2580–0.7692)
cg06566239a 0.0000 (0.0000–0.0000) 0.6584 (0.4027–0.9141) 0.3416 (0.0859–0.5973) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg00618725a 0.0000 (0.0000–0.0000) 0.6405 (0.2705–1.0106) 0.3595 (− 0.0106–0.7295) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg14312783a 0.0000 (0.0000–0.0000) 0.5993 (0.2752–0.9234) 0.4007 (0.0766–0.7248) 0.0000 (0.0000–0.0000) 0.3585 (− 1.1327–1.8496) 0.6415 (− 0.8496–2.1327)
cg24420981a 0.0000 (0.0000–0.0000) 0.5814 (0.0205–1.1423) 0.4186 (− 0.1423–0.9795) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg11223735a 0.0000 (0.0000–0.0000) 0.5367 (0.1905–0.8829) 0.4633 (0.1171–0.8095) 0.4334 (NaN–NaN) 0.0000 (0.0000–0.0000) 0.5666 (NaN–NaN)
cg16648911a 0.0000 (0.0000–0.0000) 0.5177 (0.2552–0.7802) 0.4823 (0.2198–0.7448) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg16698623a 0.0000 (0.0000–0.0000) 0.5145 (0.2241–0.8050) 0.4855 (0.1950–0.7759) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg17307615a 0.0000 (0.0000–0.0000) 0.5057 (0.1429–0.8685) 0.4943 (0.1315–0.8571) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg19806483a 0.0000 (0.0000–0.0000) 0.4869 (0.0110–0.9628) 0.5131 (0.0372–0.9890) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg18485261a 0.0000 (0.0000–0.0000) 0.4861 (0.0492–0.9230) 0.5139 (0.0770–0.9508) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg11948988a 0.0000 (0.0000–0.0000) 0.4843 (0.0623–0.9064) 0.5157 (0.0936–0.9377) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg25946389a 0.0000 (0.0000–0.0000) 0.4715 (0.0162–0.9269) 0.5285 (0.0731–0.9838) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg17380475a 0.0000 (0.0000–0.0000) 0.4228 (0.1566–0.6890) 0.5772 (0.3110–0.8434) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg19680672a 0.0000 (0.0000–0.0000) 0.4005 (0.1212–0.6798) 0.5995 (0.3202–0.8788) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg26528551a 0.0000 (0.0000–0.0000) 0.3832 (0.1061–0.6604) 0.6168 (0.3396–0.8939) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg15312358a 0.0000 (0.0000–0.0000) 0.3783 (0.0587–0.6980) 0.6217 (0.3020–0.9413) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg19706602a 0.0000 (0.0000–0.0000) 0.3529 (0.0763–0.6296) 0.6471 (0.3704–0.9237) 0.0000 (0.0000–0.0000) 0.2628 (− 0.0376–0.5632) 0.7372 (0.4368–1.0376)
cg26976729a 0.0000 (0.0000–0.0000) 0.3230 (0.0260–0.6199) 0.6770 (0.3801–0.9740) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg13171643a 0.0000 (0.0000–0.0000) 0.3145 (0.0155–0.6135) 0.6855 (0.3865–0.9845) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg25557018a 0.0000 (0.0000–0.0000) 0.3061 (0.0044–0.6077) 0.6939 (0.3923–0.9956) 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000)
cg27000233b 0.0000 (0.0000–0.0000) 0.3263 (NaN–NaN) 0.6737 (NaN–NaN) 0.0000 (0.0000–0.0000) 0.3029 (0.1708–0.4349) 0.6971 (0.5651–0.8292)
cg14194875b 0.0000 (0.0000–0.0000) 0.2670 (− 0.0342–0.5682) 0.7330 (0.4318–1.0342) 0.0000 (0.0000–0.0000) 0.6596 (0.3137–1.0056) 0.3404 (− 0.0056–0.6863)
cg27483317b 0.7057 (0.4854–0.9261) 0.0000 (0.0000–0.0000) 0.2943 (0.0739–0.5146) 0.0000 (0.0000–0.0000) 0.5641 (0.2106–0.9176) 0.4359 (0.0824–0.7894)
cg07367735b 0.3773 (− 0.0659–0.8206) 0.0000 (0.0000–0.0000) 0.6227 (0.1794–1.0659) 0.0000 (0.0000–0.0000) 0.5802 (0.0485–1.1119) 0.4198 (− 0.1119–0.9515)
cg05596517b 0.3609 (− 0.0911–0.8130) 0.0000 (0.0000–0.0000) 0.6391 (0.1870–1.0911) 0.0000 (0.0000–0.0000) 0.5740 (0.1702–0.9779) 0.4260 (0.0221–0.8298)
cg00639517b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.4576 (0.1108–0.8045) 0.5424 (0.1955–0.8892)
cg04540870b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.2222 (0.1253–0.3190) 0.7778 (0.6810–0.8747)
cg05068430b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.6789 (0.3242–1.0335) 0.3211 (− 0.0335–0.6758)
cg07448909b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3512 (0.0368–0.6656) 0.6488 (0.3344–0.9632)
cg09154334b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3255 (0.0383–0.6127) 0.6745 (0.3873–0.9617)
cg11019008b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.4915 (0.0430–0.9400) 0.5085 (0.0600–0.9570)
cg11216456b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3477 (0.0523–0.6431) 0.6523 (0.3569–0.9477)
cg11235543b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3398 (0.2386–0.4410) 0.6602 (0.5590–0.7614)
cg23235067b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.4256 (0.1038–0.7473) 0.5744 (0.2527–0.8962)
cg24747557b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3091 (0.0123–0.6058) 0.6909 (0.3942–0.9877)
cg27429313b 0.0000 (0.0000–0.0000) 0.0000 (0.0000–0.0000) 1.0000 (1.0000–1.0000) 0.0000 (0.0000–0.0000) 0.3577 (0.0478–0.6677) 0.6423 (0.3323–0.9522)
  1. a,bRepresent significant CpG sites with significant common environmental component with 0 not included in the 2.5–97.5% confidence intervals in 1997 and 2007, respectively
  2. cRepresents overlapped significant CpG sites between 1997 and 2007 with common environmental component