Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats

Fig. 7

Peri-SCN area dopaminergic lesion increased adipose and liver lipogenic enzyme mRNA levels. Animals received an infusion of 6-OHDA (2–4 μg/side) at the peri-SCN area bilaterally, data were collected 17 weeks post-lesion. a Peri-SCN area dopaminergic 6-OHDA lesion (n = 14) impact on mRNA expression for the following genes in the adipose tissue vs vehicle (n = 8): PEPCK1, PEPCK2, G6PDH, FAS, HSL, PDHx, ACC, ME (b) Peri-SCN area dopaminergic lesion impact on mRNA expression for the following genes in the liver: G6PDH, ACC, FAS, CPT1, MCP1, TNFa. Data are represented as the mean ± SEM. * P < 0.05 (2-tailed Student’s t-test) or † P  < 0.05 significant difference between treatment groups (1-tailed Student’s t-test)

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