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Table 2 Comparisons between fed and fasted groups following oral administration of lotilaner at 6 mg/kg

From: Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats

Parameter Ratio (fasted to fed) 90% CI t-value P-valuea
T1/2z 0.806 0.503–1.291 t(22) = -0.79 0.4397
MRT 0.789 0.504–1.234 t(22) = -0.91 0.3730
Cmax (dose normalized) 0.108 0.073–0.159 t(15) = -10.05 < 0.0001
AUClast (dose normalized) 0.080 0.058–0.110 t(22) = -13.44 < 0.0001
AUCinf (dose normalized) 0.067 0.044–0.100 t(22) = -11.33 < 0.0001
Bioavailability 0.080 0.058–0.110 t(22) = -13.44 < 0.0001
  1. aP-values < 0.0001 denote significance