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Table 1 Mean ± standard deviation pharmacokinetic parameters of lotilaner in adult cats after either single administration at a target dose of 6 mg/kg orally to fasted cats orally to fed cats, or at a target dose of 3.0 mg/kg intravenously. All values (mean and standard deviation) are based on geometric summary statistics (corresponding to summary statistics of log-transformed values and then back-transformed), except for Tmax which is based on the median

From: Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats

Parameter Intravenous, 3 mg/kg
(n = 8)
Oral, fed 6 mg/kg
(n = 11) b
Oral, fasted 6 mg/kg
(n = 6)
Actual doses (mg/kg) 3.07 ± 0.07 7.52 ± 0.83 8.00 ± 0.70
Tmax (hours) na 4 (range: 1–24) 2 (range: 1–4)
Cmax (ng/ml) na 3004 ± 709 348 ± 249
AUClast (day*ng/ml) 13,238 ± 2839 33,907 ± 6611 2901 ± 2207
AUCinf (day*ng/ml) 23,776 ± 9131 68,418 ± 23,220 4876 ± 3610
Cmax (dose normalized) (ng/ml)a na 403.4 ± 107.0 43.6 ± 28.6
AUClast (dose normalized) (day*ng/ml)a 4315 ± 862 4554 ± 762 364 ± 255
AUCinf (dose normalized) (day*ng/ml)a 7750 ± 2876 9188 ± 3632 612 ± 420
T1/2z (day) 28.6 ± 14.3 33.6 ± 22.0 27.1 ± 7.7
MRT (day) 41.6 ± 19.5 48.9 ± 30.7 38.6 ± 9.9
CL (l/kg/day) 0.13 ± 0.05 na na
Vz (l/kg) 5.34 ± 1.49 na na
Vss (l/kg) 5.37 ± 1.37 na na
Bioavailability (F%) na 106 8.4
  1. aDose-normalized to 1 mg/kg
  2. aOne cat had an adverse event unrelated to the treatment (leg fracture) and was withdrawn from the study